Secretory Unit of Islet Transplant Objects (SUITO) Index Can Predict Outcome of Intravenous Glucose Tolerance Test

• Published in: Transplantation proceedings Vol. 42; no. 6; pp. 2065 - 2067
• Main Authors: Takita, M, Matsumoto, S, Noguchi, H, Shimoda, M, Chujo, D, Itoh, T, Sugimoto, K, Tamura, Y, Olsen, G.S, Naziruddin, B, Onaca, N, Levy, M.F
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Inc 01.07.2010; Elsevier
• Subjects: Biological and medical sciences; Blood Glucose - metabolism; C-Peptide - blood; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - surgery; Environmental Monitoring - methods; Fasting; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Glucose Tolerance Test; Humans; Islets of Langerhans Transplantation - physiology; Medical sciences; ROC Curve; Sensitivity and Specificity; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; Prognosis; Intravenous administration; Langerhans islet; Prediction; Homograft; Glucose tolerance test; Index; Health service; Transplantation; Unit; Medicine; Treatment; Surgery; Evolution; Graft; Object; Predictive factor; Endocrine pancreas
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2010.05.102

Abstract Background Simple monitoring of engrafted islet function is important for follow-up of recipients after islet transplantation. We previously developed a simple assessment tool for islet graft function; the secretory unit of islet transplant objects (SUITO) index. The aim of this study was to clarify the relationship between the SUITO index and the outcomes of intravenous glucose tolerance tests (IVGTT). Methods Fifteen series of blood samples from 6 islet recipients were collected before 3, 5, 10, 20, and 30 minutes after injection of 0.5 g/kg 50% dextrose. The SUITO index was calculated using plasma C-peptide and glucose level at fasting baseline. Samples were divided into the following 3 groups; low-SUITO (SUITO index <10; n = 3); middle-SUITO (SUITO index ≥10 to <26; n = 4); and high-SUITO (SUITO index ≥26; n = 8). Results A threshold SUITO index of 26 showed good sensitivity (85.7%) and specificity (75.0%) to predict a blood glucose level of >10 mmol/L at 30 minutes. Blood glucose levels in the low-SUITO group were significantly higher than among the other 2 groups at baseline and 10, 20 and 30 minutes ( P < .05). Glucose-level areas under the receiver-operating characteristic curve during IVGTT in the low-SUITO group were also significantly larger than among the other 2 groups ( P < .05). Conclusion The SUITO index, using only a fasting blood sample, predicted IVGTT outcomes.