Sodium bicarbonate and salbutamol facilitate recovery from hyperkalemia-induced electrocardiogram abnormalities in bullfrog hearts

• Published in: Journal of Veterinary Medical Science Vol. 85; no. 10; pp. 1063 - 1067
• Main Authors: AZUMA, Saya, KUWANA, Ryo, NARISAWA, Ken, KAZAMA, Itsuro
• Format: Journal Article
• Language: English
• Published: Tokyo JAPANESE SOCIETY OF VETERINARY SCIENCE 2023; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: bullfrog heart; EKG; electrocardiogram (ECG); Hyperkalemia; Kidney diseases; Na+/K+-exchanging ATPase; Physiology; Potassium chloride; Salbutamol; Sodium bicarbonate

Hyperkalemia is a common electrolyte abnormality frequently complicated with chronic kidney disease. By injecting potassium chloride (KCl) solutions intravenously into bullfrogs, we reproduced typical electrocardiogram (ECG) abnormalities of hyperkalemia in the frog hearts, such as the peaked T wave...