Cancer stem cells promote lymph nodes metastasis of breast cancer by reprogramming tumor microenvironment

• Published in: Translational oncology Vol. 35; p. 101733
• Main Authors: Li, Lin, Liu, Jianyu, Wang, Wenzheng, Fu, Yingqiang, Deng, Yuhan, Li, Xin, Liu, Zhuolin, Pang, Yuheng, Xu, Yangyang, Yan, Meisi, Li, Zhigao
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2023; Neoplasia Press; Elsevier
• Subjects: Breast cancer 1; Cancer stem cells (CSCs) 2; Lymph node metastasis 5; Single-cell RNA sequencing (scRNA-seq) 4; Tumor immune microenvironment (TIME) 3; Tumor immune microenvironment (TIME) 3; Lymph node metastasis 5; Single-cell RNA sequencing (scRNA-seq) 4; Cancer stem cells (CSCs) 2; Breast cancer 1

•Breast cancer stem cells (CSCs) alter tumor immune microenvironment to promote lymph node metastasis.•RAC2 and PTTG1 double-positive CSCs exhibit stem-like features and are enriched in metastatic lymph nodes.•CSCs impact the evolution of adaptive and innate immune cells, contributing to metastasis...