Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development

Protein arginine methylation is a common post-translational modification involved in the regulation of various cellular functions. Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that asymmetrically dimethylates histone H3 and non-histone proteins...

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Published inGenes & diseases Vol. 10; no. 6; pp. 2383 - 2392
Main Authors Ma, Zhongrui, Lyu, Xinxing, Qin, Ning, Liu, Haoyu, Zhang, Mengrui, Lai, Yongchao, Dong, Bo, Lu, Peiyuan
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.11.2023
Chongqing Medical University
KeAi Communications Co., Ltd
Subjects
Arginine methylation
CARM1
Cell differentiation
Development
Epigenetic regulation
Review
Development
Epigenetic regulation
Cell differentiation
CARM1
Arginine methylation
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Summary:Protein arginine methylation is a common post-translational modification involved in the regulation of various cellular functions. Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that asymmetrically dimethylates histone H3 and non-histone proteins to regulate gene transcription. CARM1 has been found to play important roles in cell differentiation and development, cell cycle progression, autophagy, metabolism, pre-mRNA splicing and transportation, and DNA replication. In this review, we describe the molecular characteristics of CARM1 and summarize its roles in the regulation of cell differentiation and development in mammals.
Bibliography:ObjectType-Article-2
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These authors contributed equally to this work.
ISSN:2352-3042
2352-4820
2352-3042
DOI:10.1016/j.gendis.2022.05.021