Multiple transatlantic incursions of highly pathogenic avian influenza clade 2.3.4.4b A(H5N5) virus into North America and spillover to mammals

• Published in: Cell reports (Cambridge) Vol. 43; no. 7; p. 114479
• Main Authors: Erdelyan, Cassidy N.G., Kandeil, Ahmed, Signore, Anthony V., Jones, Megan E.B., Vogel, Peter, Andreev, Konstantin, Bøe, Cathrine Arnason, Gjerset, Britt, Alkie, Tamiru N., Yason, Carmencita, Hisanaga, Tamiko, Sullivan, Daniel, Lung, Oliver, Bourque, Laura, Ayilara, Ifeoluwa, Pama, Lemarie, Jeevan, Trushar, Franks, John, Jones, Jeremy C., Seiler, Jon P., Miller, Lance, Mubareka, Samira, Webby, Richard J., Berhane, Yohannes
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.07.2024; Elsevier
• Subjects: A(H5N5); Animals; antiviral susceptibility; avian influenza; Birds - virology; clade 2.3.4.4b; contact transmission; CP: Microbiology; ferret model; Ferrets; HPAI; Humans; Influenza A virus - genetics; Influenza A virus - pathogenicity; Influenza in Birds - transmission; Influenza in Birds - virology; Mammals - virology; North America - epidemiology; Orthomyxoviridae Infections - transmission; Orthomyxoviridae Infections - virology; Phylogeny; Sable Island; wildlife transmission; North America; HPAI; contact transmission; avian influenza; wildlife transmission; CP: Microbiology; A(H5N5); antiviral susceptibility; Sable Island; clade 2.3.4.4b; ferret model

Highly pathogenic avian influenza (HPAI) viruses have spread at an unprecedented scale, leading to mass mortalities in birds and mammals. In 2023, a transatlantic incursion of HPAI A(H5N5) viruses into North America was detected, followed shortly thereafter by a mammalian detection. As these A(H5N5)...