NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes

• Published in: Scientific reports Vol. 10; no. 1; p. 16087
• Main Authors: Chen, Yng-Tay, Lin, Wei-De, Liao, Wen-Ling, Tsai, Ya-Ching, Liao, Jiunn-Wang, Tsai, Fuu-Jen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.09.2020; Nature Publishing Group
• Subjects: 5'-Nucleotidase - genetics; 631/208/176; 692/53/2423; Adult; Aged; Animals; Antigens, CD - genetics; Astrocytes; Beta cells; Case-Control Studies; Cerebral infarction; Deoxyribonucleic acid; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; DNA; DNA (Cytosine-5-)-Methyltransferase 1 - genetics; DNA Methylation; DNA methyltransferase; DNMT1 protein; Epigenesis, Genetic; Epigenetics; Female; Fucosyltransferases - genetics; Gene expression; Gene Expression Regulation; Gene silencing; Genetic diversity; Genome-wide association studies; Genomes; Glial fibrillary acidic protein; Humanities and Social Sciences; Humans; Insulin; Insulin - metabolism; Insulin secretion; Insulin-like growth factor I; Insulin-like growth factors; Insulin-Secreting Cells - metabolism; Ischemia; Male; Mice; Middle Aged; multidisciplinary; Neurogenesis; Neurological diseases; Nucleotidase; Pancreas; Polyethylene; Polyethylene glycol; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Receptor, Insulin - genetics; RNA, Messenger - blood; RNA, Messenger - genetics; Rodents; Science; Science (multidisciplinary); Serum levels; Signal Transduction; Single-nucleotide polymorphism; Stroke; Synaptophysin; Transfection

Epigenetics alternation of non-genetic variation and genome-wide association study proven allelic variants may associate with insulin secretion in type 2 diabetes (T2D) development. We analyzed promoter DNA methylation array to evaluate the associated with increased susceptibility to T2D (30 cases,...