Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol

• Published in: Molecular biology of the cell Vol. 14; no. 1; pp. 334 - 347
• Main Authors: Labrecque, Lyne, Royal, Isabelle, Surprenant, David S, Patterson, Cam, Gingras, Denis, Béliveau, Richard
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 01.01.2003
• Subjects: Caveolin 1; Caveolins - metabolism; Cell Membrane - metabolism; Cholesterol - metabolism; Humans; Oligopeptides - metabolism; Phosphorylation; Receptors, Vascular Endothelial Growth Factor - metabolism; Signal Transduction - physiology; Tyrosine - metabolism

The stimulation of vascular endothelial growth factor receptor-2 (VEGFR-2) by tumor-derived VEGF represents a key event in the initiation of angiogenesis. In this work, we report that VEGFR-2 is localized in endothelial caveolae, associated with caveolin-1, and that this complex is rapidly dissociat...