Prolonged SARS-CoV-2 infection associated with long-term corticosteroid use in a patient with impaired B-cell immunity

• Published in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Vol. 28; no. 7; pp. 971 - 974
• Main Authors: Morishita, Momoko, Suzuki, Manabu, Matsunaga, Akihiro, Ishizhima, Keishi, Yamamoto, Tsukasa, Kuroda, Yudai, Kanno, Takayuki, Tsujimoto, Yoshie, Ishida, Akane, Hashimoto, Masao, Ishii, Satoru, Takasaki, Jin, Naka, Go, Iikura, Motoyasu, Izumi, Shinyu, Suzuki, Tadaki, Maeda, Ken, Ishizaka, Yukihito, Hojo, Masayuki, Sugiyama, Haruhito
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.07.2022; Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd
• Subjects: Antibodies, Viral; Case Report; Corticosteroids; COVID-19; COVID-19 Drug Treatment; Humans; Immunocompromised; Immunocompromised Host; Male; Rituximab; Rituximab - adverse effects; SARS-CoV-2; SARS-CoV-2 infection; Viral shedding; COVID-19; SARS-CoV-2 infection; Rituximab; Corticosteroids; Viral shedding; Immunocompromised

Corticosteroids are widely used to treat severe COVID-19, but in immunocompromised individuals, who are susceptible to persistent infection, long term corticosteroid use may delay viral clearance. We present a case of prolonged SARS-CoV-2 infection in a man with significantly impaired B-cell immunit...