Evaluating the Use of Sacran, a Polysaccharide Isolated from Aphanothece sacrum, as a Possible Microbicide for Preventing HIV-1 Infection

• Published in: Viruses Vol. 16; no. 9; p. 1501
• Main Authors: Matsuda, Kouki, Kariya, Ryusho, Maeda, Kenji, Okada, Seiji
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.09.2024; MDPI
• Subjects: Acids; Acquired immune deficiency syndrome; AIDS; Anti-HIV Agents - pharmacology; Anti-infective agents; Anti-Infective Agents - pharmacology; anti-inflammatory activity; antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Antiviral agents; Aphanothece; Aphanothece sacrum; biocompatible materials; Biomaterials; Cell fusion; Cell Line; Complications and side effects; Convalescence; Cyanobacteria; Cyanobacteria - chemistry; Cytotoxicity; Disease transmission; disinfectants; Dosage and administration; Drug development; Drug resistance; GLP-1 receptor agonists; Health aspects; HIV; HIV (Viruses); HIV infections; HIV Infections - prevention & control; HIV Infections - virology; HIV-1; HIV-1 - drug effects; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; hydrogels; Immune system; immunosuppression; Infections; Lymphocytes; microbicide; mortality; Penicillin; Polysaccharides; Polysaccharides - pharmacology; Polysaccharides, Bacterial - pharmacology; Polyvinyl alcohol; Prevention; Reagents; Risk factors; sacran; Sacrum; Sexually transmitted diseases; Software; STD; therapeutics; Viral infections; Virus Internalization - drug effects; Viruses; Japan; United States > US; HIV-1; sacran; microbicide

Since combination antiretroviral therapy (cART) was introduced to treat human immunodeficiency virus type-1 (HIV-1)/acquired immunodeficiency syndrome (AIDS), the AIDS mortality rate has markedly decreased, and convalescence in individuals with HIV has improved drastically. However, sexual transmiss...