Mapping the distribution of serotonin transporter in the human brainstem with high-resolution PET: Validation using postmortem autoradiography data

• Published in: NeuroImage (Orlando, Fla.) Vol. 133; pp. 313 - 320
• Main Authors: Fazio, P., Schain, M., Varnäs, K., Halldin, C., Farde, L., Varrone, A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2016; Elsevier Limited
• Subjects: Adult; Age; Aged; Autopsy - methods; Autoradiography - methods; Benzylamines - pharmacokinetics; Brain research; Brain Stem - chemistry; Brain Stem - metabolism; Brainstem nuclei; Female; Humans; Imaging, Three-Dimensional - methods; Magnetic Resonance Imaging - methods; Male; Medical imaging; Methods; Middle Aged; Molecular Imaging - methods; NMR; Nuclear magnetic resonance; Nuclear medicine; PET template-based analysis; Positron-Emission Tomography - methods; Radiopharmaceuticals - pharmacokinetics; Serotonin; Serotonin Plasma Membrane Transport Proteins - chemistry; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin transporter; Studies; Tissue Distribution; PET template-based analysis; Brainstem nuclei; Serotonin transporter

The human brainstem is a complex structure with several small nuclei and neural pathways of interest in the pathophysiology of central nervous system (CNS) disorders. In common with other monoaminergic systems, serotoninergic neurons originate from a group of nuclei located in the brainstem. The pre...