INHALATION OF POORLY SOLUBLE PARTICLES. II. INFLUENCE OF PARTICLE SURFACE AREA ON INFLAMMATION AND CLEARANCE

• Published in: Inhalation toxicology Vol. 12; no. 12; pp. 1113 - 1126
• Main Authors: Tran, C L, Buchanan, D, Cullen, R T, Searl, A, Jones, A D, Donaldson, K
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.12.2000; Taylor & Francis
• Subjects: Administration, Inhalation; Animals; Barium Sulfate - toxicity; Body Burden; Dust - adverse effects; Inflammation - etiology; Lung - drug effects; Lung - metabolism; Lymph Nodes - metabolism; Male; Metabolic Clearance Rate; Neutrophils - drug effects; Rats; Rats, Wistar; Titanium - toxicity

In this article the volumetric overload hypothesis, which predicts the impairment of clearance of particles deposited in the lung in terms of particle volume, is reevaluated. The degree to which simple expressions of retained lung burden explain pulmonary responses to overload was investigated using...