Metabolic engineering of Streptomyces to enhance the synthesis of valuable natural products

The mycelial bacterium Streptomyces is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its complicated life cycle, silent biosynthetic gene clusters (BGCs), and poorly characterized metabolic mechanisms limit efficient production of...

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Published inEngineering Microbiology Vol. 2; no. 2; p. 100022
Main Authors Xu, Zuwei, Ji, Lihao, Tang, Wenxiu, Guo, Liang, Gao, Cong, Chen, Xiulai, Liu, Jia, Hu, Guipeng, Liu, Liming
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2022
Elsevier
Subjects
Biosynthetic gene clusters
Life cycle
Metabolic engineering
Natural products
Review
Streptomyces
NPs
Life cycle
FDA
C-di-GMP
TAR
Natural products
Biosynthetic gene clusters
Streptomyces
Metabolic engineering
BGCs
(p)ppGpp
C-di-AMP
Online AccessGet full text
ISSN2667-3703
2097-4280
2667-3703
DOI10.1016/j.engmic.2022.100022

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Abstract The mycelial bacterium Streptomyces is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its complicated life cycle, silent biosynthetic gene clusters (BGCs), and poorly characterized metabolic mechanisms limit efficient production of natural products. Therefore, a metabolic engineering strategy, including traditional and emerging tools from different disciplines, was developed to further enhance natural product synthesis by Streptomyces. Here, current trends in systems metabolic engineering, including tools and strategies, are reviewed. Particularly, this review focuses on recent developments in the selection of methods for regulating the Streptomyces life cycle, strategies for the activation of silent gene clusters, and the exploration of regulatory mechanisms governing antibiotic production. Finally, future challenges and prospects are discussed. [Display omitted]
AbstractList The mycelial bacterium Streptomyces is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its complicated life cycle, silent biosynthetic gene clusters (BGCs), and poorly characterized metabolic mechanisms limit efficient production of natural products. Therefore, a metabolic engineering strategy, including traditional and emerging tools from different disciplines, was developed to further enhance natural product synthesis by Streptomyces. Here, current trends in systems metabolic engineering, including tools and strategies, are reviewed. Particularly, this review focuses on recent developments in the selection of methods for regulating the Streptomyces life cycle, strategies for the activation of silent gene clusters, and the exploration of regulatory mechanisms governing antibiotic production. Finally, future challenges and prospects are discussed.
The mycelial bacterium Streptomyces is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its complicated life cycle, silent biosynthetic gene clusters (BGCs), and poorly characterized metabolic mechanisms limit efficient production of natural products. Therefore, a metabolic engineering strategy, including traditional and emerging tools from different disciplines, was developed to further enhance natural product synthesis by Streptomyces. Here, current trends in systems metabolic engineering, including tools and strategies, are reviewed. Particularly, this review focuses on recent developments in the selection of methods for regulating the Streptomyces life cycle, strategies for the activation of silent gene clusters, and the exploration of regulatory mechanisms governing antibiotic production. Finally, future challenges and prospects are discussed.The mycelial bacterium Streptomyces is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its complicated life cycle, silent biosynthetic gene clusters (BGCs), and poorly characterized metabolic mechanisms limit efficient production of natural products. Therefore, a metabolic engineering strategy, including traditional and emerging tools from different disciplines, was developed to further enhance natural product synthesis by Streptomyces. Here, current trends in systems metabolic engineering, including tools and strategies, are reviewed. Particularly, this review focuses on recent developments in the selection of methods for regulating the Streptomyces life cycle, strategies for the activation of silent gene clusters, and the exploration of regulatory mechanisms governing antibiotic production. Finally, future challenges and prospects are discussed.
The mycelial bacterium Streptomyces is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its complicated life cycle, silent biosynthetic gene clusters (BGCs), and poorly characterized metabolic mechanisms limit efficient production of natural products. Therefore, a metabolic engineering strategy, including traditional and emerging tools from different disciplines, was developed to further enhance natural product synthesis by Streptomyces . Here, current trends in systems metabolic engineering, including tools and strategies, are reviewed. Particularly, this review focuses on recent developments in the selection of methods for regulating the Streptomyces life cycle, strategies for the activation of silent gene clusters, and the exploration of regulatory mechanisms governing antibiotic production. Finally, future challenges and prospects are discussed. Image, graphical abstract
The mycelial bacterium Streptomyces is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its complicated life cycle, silent biosynthetic gene clusters (BGCs), and poorly characterized metabolic mechanisms limit efficient production of natural products. Therefore, a metabolic engineering strategy, including traditional and emerging tools from different disciplines, was developed to further enhance natural product synthesis by Streptomyces. Here, current trends in systems metabolic engineering, including tools and strategies, are reviewed. Particularly, this review focuses on recent developments in the selection of methods for regulating the Streptomyces life cycle, strategies for the activation of silent gene clusters, and the exploration of regulatory mechanisms governing antibiotic production. Finally, future challenges and prospects are discussed. [Display omitted]
The mycelial bacterium is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its complicated life cycle, silent biosynthetic gene clusters (BGCs), and poorly characterized metabolic mechanisms limit efficient production of natural products. Therefore, a metabolic engineering strategy, including traditional and emerging tools from different disciplines, was developed to further enhance natural product synthesis by . Here, current trends in systems metabolic engineering, including tools and strategies, are reviewed. Particularly, this review focuses on recent developments in the selection of methods for regulating the life cycle, strategies for the activation of silent gene clusters, and the exploration of regulatory mechanisms governing antibiotic production. Finally, future challenges and prospects are discussed.
ArticleNumber 100022
Author Hu, Guipeng
Tang, Wenxiu
Gao, Cong
Xu, Zuwei
Ji, Lihao
Liu, Jia
Guo, Liang
Chen, Xiulai
Liu, Liming
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  organization: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
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  surname: Tang
  fullname: Tang, Wenxiu
  organization: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
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  givenname: Liming
  surname: Liu
  fullname: Liu, Liming
  email: mingll@jiangnan.edu.cn
  organization: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
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Issue 2
Keywords NPs
Life cycle
FDA
C-di-GMP
TAR
Natural products
Biosynthetic gene clusters
Streptomyces
Metabolic engineering
BGCs
(p)ppGpp
C-di-AMP
Language English
License This is an open access article under the CC BY license.
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Snippet The mycelial bacterium Streptomyces is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its...
The mycelial bacterium is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its complicated...
The mycelial bacterium Streptomyces is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its...
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SubjectTerms Biosynthetic gene clusters
Life cycle
Metabolic engineering
Natural products
Review
Streptomyces
Title Metabolic engineering of Streptomyces to enhance the synthesis of valuable natural products
URI https://dx.doi.org/10.1016/j.engmic.2022.100022
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