Fecal microbiota transplantation in inflammatory bowel disease: the quest for the holy grail

• Published in: Mucosal immunology Vol. 9; no. 6; pp. 1360 - 1365
• Main Authors: Pigneur, B., Sokol, H.
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.11.2016; Nature Publishing Group US; Elsevier Limited; Nature Pub. Group
• Subjects: 631/250/347; 692/4020/1503/1581/257; 692/4020/2741/2135; 692/700/565/545/576; Allergology; Animals; Antibodies; Biomedical and Life Sciences; Biomedicine; Colitis, Ulcerative - etiology; Colitis, Ulcerative - therapy; Crohn Disease - etiology; Crohn Disease - therapy; Fecal Microbiota Transplantation - adverse effects; Fecal Microbiota Transplantation - methods; Feces - microbiology; Gastroenterology; Human health and pathology; Humans; Hépatology and Gastroenterology; Immunology; Inflammatory Bowel Diseases - etiology; Inflammatory Bowel Diseases - therapy; Life Sciences; Microbiota; review; Time Factors; Tissue Donors; Treatment Outcome; intestinal microbiota; crohns-disease; donor; chronic pouchitis; children; host; clostridium-difficile infection; randomized controlled-trial; frozen; ulcerative-colitis

Inflammatory bowel disease (IBD) is due to an aberrant immune response toward luminal antigens, probably commensal bacteria, in genetically susceptible subjects and is also influenced by environmental factors. An imbalanced intestinal microbiota known as “dysbiosis,” characterized by an increased pr...