Way to efficient microbial paclitaxel mass production

• Published in: Synthetic and systems biotechnology Vol. 8; no. 4; pp. 673 - 681
• Main Authors: Li, Chenyue, Qi, Yanli, Sun, Zhongke, Jiang, Mengwan, Li, Chengwei
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.12.2023; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Endophytes; Microbial fermentation; Paclitaxel; Process optimization; Review; Synthetic pathway; Endophytes; Process optimization; Synthetic pathway; Microbial fermentation; Paclitaxel

The microbial synthesis of paclitaxel is attractive for its short-cycle, cost-effectiveness, and sustainability. However, low paclitaxel productivity, depleted capacity during subculture and storage, and unclear biosynthesis mechanisms restrain industrial microbial synthesis. Along with the isolatio...