The HLA-II immunopeptidome of SARS-CoV-2

• Published in: Cell reports (Cambridge) Vol. 43; no. 1; p. 113596
• Main Authors: Weingarten-Gabbay, Shira, Chen, Da-Yuan, Sarkizova, Siranush, Taylor, Hannah B., Gentili, Matteo, Hernandez, Gabrielle M., Pearlman, Leah R., Bauer, Matthew R., Rice, Charles M., Clauser, Karl R., Hacohen, Nir, Carr, Steven A., Abelin, Jennifer G., Saeed, Mohsan, Sabeti, Pardis C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.01.2024; Elsevier
• Subjects: antigen processing and presentation; CD4+ T cell; CP: Immunology; CP: Microbiology; HLA-II; immunity; immunopeptidome; noncanonical protein; SARS-CoV-2; viral antigen; CP: Immunology; SARS-CoV-2; CD4+ T cell; noncanonical protein; CP: Microbiology; immunopeptidome; HLA-II; antigen processing and presentation; immunity; viral antigen; CD4(+) T cell

Targeted synthetic vaccines have the potential to transform our response to viral outbreaks, yet the design of these vaccines requires a comprehensive knowledge of viral immunogens. Here, we report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peptides that are naturally processed and...