Poly(2‐Hydroxyethyl Methacrylate) Hydrogel‐Based Microneedles for Metformin Release

• Published in: Global challenges Vol. 7; no. 8; pp. 2300002 - n/a
• Main Authors: Sharma, Manoj B., Kap, Özlem, Abdelmohsen, Hend A. M., Ashton, Mark D., Harper, Garry R., Firlak, Melike, Aaltonen, Jasmine E., Bolland, Kerry A., Bragg, Ryan, Deeley, Sarah, Francis, Ella, Kazi, Nahin, Mapley, Bethany L., Oikonomou, Vasileios, Aljohani, Amal D., Cheneler, David, Kilic, Volkan, Horzum, Nesrin, Hardy, John G.
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.08.2023; John Wiley and Sons Inc; Wiley
• Subjects: aging; Arrays; CAD; Cancer; Computer aided design; Diabetes; Diabetes mellitus; Drug delivery; Drug delivery systems; Hydrogels; Mechanical properties; Mechanics; Metformin; microneedles; Needles; Polyhydroxyethyl methacrylate; Polymers; Skin; Swelling; Temperature; Temperature dependence; microneedles; cancer; hydrogels; aging; drug delivery; diabetes

The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2‐hydroxyethyl methacrylate), pHEMA, hydrogel‐based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical p...