Poly(2‐Hydroxyethyl Methacrylate) Hydrogel‐Based Microneedles for Metformin Release

The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2‐hydroxyethyl methacrylate), pHEMA, hydrogel‐based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical p...

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Published inGlobal challenges Vol. 7; no. 8; pp. 2300002 - n/a
Main Authors Sharma, Manoj B., Kap, Özlem, Abdelmohsen, Hend A. M., Ashton, Mark D., Harper, Garry R., Firlak, Melike, Aaltonen, Jasmine E., Bolland, Kerry A., Bragg, Ryan, Deeley, Sarah, Francis, Ella, Kazi, Nahin, Mapley, Bethany L., Oikonomou, Vasileios, Aljohani, Amal D., Cheneler, David, Kilic, Volkan, Horzum, Nesrin, Hardy, John G.
Format Journal Article
LanguageEnglish
Published Germany John Wiley & Sons, Inc 01.08.2023
John Wiley and Sons Inc
Wiley
Subjects
aging
Arrays
CAD
Cancer
Computer aided design
Diabetes
Diabetes mellitus
Drug delivery
Drug delivery systems
Hydrogels
Mechanical properties
Mechanics
Metformin
microneedles
Needles
Polyhydroxyethyl methacrylate
Polymers
Skin
Swelling
Temperature
Temperature dependence
microneedles
cancer
hydrogels
aging
drug delivery
diabetes
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Abstract The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2‐hydroxyethyl methacrylate), pHEMA, hydrogel‐based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature‐dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel‐based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc. Microneedle arrays are minimally invasive drug delivery devices that can be designed to deliver a variety of payloads the skin and other targets. Here, their application for the release of metformin in vitro is reported, which may combat aging, cancer, diabetes, etc.
AbstractList The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.
Abstract The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2‐hydroxyethyl methacrylate), pHEMA, hydrogel‐based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature‐dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel‐based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.
The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.
The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.
The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2‐hydroxyethyl methacrylate), pHEMA, hydrogel‐based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature‐dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel‐based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc. Microneedle arrays are minimally invasive drug delivery devices that can be designed to deliver a variety of payloads the skin and other targets. Here, their application for the release of metformin in vitro is reported, which may combat aging, cancer, diabetes, etc.
Author Firlak, Melike
Kap, Özlem
Horzum, Nesrin
Ashton, Mark D.
Aaltonen, Jasmine E.
Hardy, John G.
Sharma, Manoj B.
Harper, Garry R.
Bragg, Ryan
Deeley, Sarah
Bolland, Kerry A.
Oikonomou, Vasileios
Kazi, Nahin
Francis, Ella
Cheneler, David
Mapley, Bethany L.
Kilic, Volkan
Abdelmohsen, Hend A. M.
Aljohani, Amal D.
AuthorAffiliation 8 Department of Electrical and Electronics Engineering Izmir Katip Celebi University Izmir 35620 Turkey
4 Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy Ain Shams University African Union Organization Street Abbassia Cairo 11566 Egypt
6 Department of Chemistry (Female Section) Faculty of Science King Abdulaziz University Jeddah‐Rabbigh 21589 Saudi Arabia
3 Department of Engineering Sciences Izmir Katip Celebi University Izmir 35620 Turkey
7 Materials Science Institute Lancaster University Lancaster LA1 4YB UK
5 Department of Chemistry Gebze Technical University Gebze 41400 Turkey
2 School of Engineering Lancaster University Lancaster LA1 4YW UK
1 Department of Chemistry Lancaster University Lancaster LA1 4YB UK
AuthorAffiliation_xml – name: 8 Department of Electrical and Electronics Engineering Izmir Katip Celebi University Izmir 35620 Turkey
– name: 2 School of Engineering Lancaster University Lancaster LA1 4YW UK
– name: 6 Department of Chemistry (Female Section) Faculty of Science King Abdulaziz University Jeddah‐Rabbigh 21589 Saudi Arabia
– name: 1 Department of Chemistry Lancaster University Lancaster LA1 4YB UK
– name: 5 Department of Chemistry Gebze Technical University Gebze 41400 Turkey
– name: 7 Materials Science Institute Lancaster University Lancaster LA1 4YB UK
– name: 4 Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy Ain Shams University African Union Organization Street Abbassia Cairo 11566 Egypt
– name: 3 Department of Engineering Sciences Izmir Katip Celebi University Izmir 35620 Turkey
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CitedBy_id crossref_primary_10_3390_bioengineering11070649
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Issue 8
Keywords microneedles
cancer
hydrogels
aging
drug delivery
diabetes
Language English
License Attribution
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This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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2021; 426
2009
2020; 305
2019; 109
2022; 43
2014; 472
2016; 13
2021; 13
2015; 26
2004; 53
2021; 15
2016; 1
2021; 12
2020; 2020
2020; 31
2023
2022; 5
2020
2022; 9
2015; 66
2022; 12
2014; 37
2022; 13
2019
2016; 497
2018
2019; 136
2017; 260
2015
2022; 628
2022; 11
2022; 307
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SSID ssj0002210388
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Snippet The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2‐hydroxyethyl methacrylate), pHEMA, hydrogel‐based microneedle...
The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle...
Abstract The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2‐hydroxyethyl methacrylate), pHEMA, hydrogel‐based...
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pubmedcentral
proquest
pubmed
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wiley
SourceType Open Website
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StartPage 2300002
SubjectTerms aging
Arrays
CAD
Cancer
Computer aided design
Diabetes
Diabetes mellitus
Drug delivery
Drug delivery systems
Hydrogels
Mechanical properties
Mechanics
Metformin
microneedles
Needles
Polyhydroxyethyl methacrylate
Polymers
Skin
Swelling
Temperature
Temperature dependence
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Title Poly(2‐Hydroxyethyl Methacrylate) Hydrogel‐Based Microneedles for Metformin Release
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fgch2.202300002
https://www.ncbi.nlm.nih.gov/pubmed/37635699
https://www.proquest.com/docview/2856196378
https://www.proquest.com/docview/2858409977
https://pubmed.ncbi.nlm.nih.gov/PMC10448145
https://doaj.org/article/d1643f58885a40e4b029c400a9c62c7b
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