Ferroptosis Signature Shapes the Immune Profiles to Enhance the Response to Immune Checkpoint Inhibitors in Head and Neck Cancer

• Published in: Advanced science Vol. 10; no. 15; pp. e2204514 - n/a
• Main Authors: Chung, Chih‐Hung, Lin, Chun‐Yu, Chen, Chih‐Yu, Hsueh, Chun‐Wei, Chang, Yao‐Wen, Wang, Chen‐Chi, Chu, Pen‐Yuan, Tai, Shyh‐Kuan, Yang, Muh‐Hwa
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.05.2023; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Apoptosis; Cancer therapies; Cells; Ferroptosis; Gene expression; Genomics; head and neck cancer; Head and Neck Neoplasms - drug therapy; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Inflammation; Interferon; Lipids; Lymphocytes; Metastasis; Mice; Papillomavirus Infections; Patients; programmed death ligand 1; Squamous Cell Carcinoma of Head and Neck - drug therapy; Tumor Microenvironment; Tumors; head and neck cancer; programmed death ligand 1; ferroptosis

As a type of immunogenic cell death, ferroptosis participates in the creation of immunoactive tumor microenvironments. However, knowledge of spatial location of tumor cells with ferroptosis signature in tumor environments and the role of ferroptotic stress in inducing the expression of immune‐relate...