One night of total sleep deprivation promotes a state of generalized hyperalgesia: A surrogate pain model to study the relationship of insomnia and pain

• Published in: Pain (Amsterdam) Vol. 154; no. 9; pp. 1613 - 1621
• Main Authors: Schuh-Hofer, Sigrid, Wodarski, Rachel, Pfau, Doreen B., Caspani, Ombretta, Magerl, Walter, Kennedy, Jeffrey D., Treede, Rolf-Detlef
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier B.V 01.09.2013; Lippincott Williams & Wilkins, Inc; Elsevier
• Subjects: Adult; Anxiety - etiology; Anxiety - psychology; Biological and medical sciences; Central sensitization; Cross-Over Studies; Descending pain control; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Female; Fibromyalgia syndrome; Fundamental and applied biological sciences. Psychology; Humans; Hyperalgesia; Hyperalgesia - physiopathology; Hyperalgesia - psychology; Male; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Pain - epidemiology; Pain - etiology; Pain - psychology; Pain Measurement; Pain Perception - physiology; Pain Threshold - physiology; Physical Stimulation; Quantitative sensory testing; Sleep deprivation; Sleep Deprivation - epidemiology; Sleep Deprivation - physiopathology; Sleep. Vigilance; Vertebrates: nervous system and sense organs; Young Adult; Central sensitization; Descending pain control; Fibromyalgia syndrome; Sleep deprivation; Quantitative sensory testing; Hyperalgesia; Nervous system diseases; Diseases of the osteoarticular system; Sleep disorder; Fibromyalgia; Striated muscle disease; Chronic; Pain; Sleep; Insomnia; Models; Sensitization; Neurological disorder

One night of total sleep deprivation results in generalized hyperalgesia and mood changes. TSD emerges a translational surrogate pain model for studies on the relationship between insomnia and pain. Sleep disturbances are highly prevalent in chronic pain patients. Understanding their relationship ha...