Overcoming Cancer Persister Cells by Stabilizing the ATF4 Promoter G‐quadruplex

• Published in: Advanced science Vol. 11; no. 35; pp. e2401748 - n/a
• Main Authors: Xiao, Chengmei, Li, Yipu, Liu, Yushuang, Dong, Ruifang, He, Xiaoyu, Lin, Qing, Zang, Xin, Wang, Kaibo, Xia, Yuanzheng, Kong, Lingyi
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.09.2024; John Wiley and Sons Inc; Wiley
• Subjects: Activating Transcription Factor 4 - genetics; Activating Transcription Factor 4 - metabolism; Amino acids; ATF4; Brain cancer; Cancer therapies; Cell death; Cell Line, Tumor; Chemotherapy; Clinical trials; coptisine; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; G-Quadruplexes; Genomes; Glutamine - genetics; Glutamine - metabolism; Glutamine - pharmacology; glutamine‐restrictive therapy; G‐quadruplex; Humans; Kinases; Lung cancer; Metabolism; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; NMR; Nuclear magnetic resonance; Physiology; Promoter Regions, Genetic - genetics; Proteins; Transcription factors; Tumors; G‐quadruplex; coptisine; ATF4; glutamine‐restrictive therapy

Persister cells (PS) selected for anticancer therapy have been recognized as a significant contributor to the development of treatment‐resistant malignancies. It is found that imposing glutamine restriction induces the generation of PS, which paradoxically bestows heightened resistance to glutamine...