Imaging the neural correlates of neuropathic pain and pleasurable relief associated with inherited erythromelalgia in a single subject with quantitative arterial spin labelling

Using a composite diagnostic-neuroimaging approach, this study shows the modulatory effects of pleasant cooling on pain-related cortical regions in a subject suffering from inherited erythromelalgia. We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the...

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Published inPain (Amsterdam) Vol. 153; no. 5; pp. 1122 - 1127
Main Authors Segerdahl, Andrew R., Xie, Jingyi, Paterson, Kathryn, Ramirez, Juan D., Tracey, Irene, Bennett, David L.H.
Format Journal Article
LanguageEnglish
Published Philadelphia, PA Elsevier B.V 01.05.2012
Lippincott Williams & Wilkins, Inc
Elsevier
Lippincott Williams & Wilkins
Subjects
Adult
Arterial spin labelling
Biological and medical sciences
Brain - physiopathology
Clinical Note
Erythromelalgia
Erythromelalgia - genetics
Erythromelalgia - physiopathology
Female
FMRI
Functional Neuroimaging - methods
Fundamental and applied biological sciences. Psychology
Humans
Illness and personality
Illness, stress and coping
NAV1.7 Voltage-Gated Sodium Channel
Neuralgia - genetics
Neuralgia - physiopathology
Neuropathic pain
Pleasure - physiology
Psychology and medicine
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Sensory Thresholds - physiology
Sodium Channels - genetics
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors
Spin Labels
Vertebrates: nervous system and sense organs
Erythromelalgia
Arterial spin labelling
FMRI
Neuropathic pain
Human
Temperature
Cooling
Hypersensitivity
Nuclear magnetic resonance imaging
Foot
Pain
Neuron
Sodium
Voltage
Mutation
Technique
Online AccessGet full text

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Abstract Using a composite diagnostic-neuroimaging approach, this study shows the modulatory effects of pleasant cooling on pain-related cortical regions in a subject suffering from inherited erythromelalgia. We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Nav1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design to assess her baseline erythromelalgia pain vs cooling relief. Robust activations of key pain, pain-affect, and reward-related centres were observed. This combined approach allowed us to confirm the presence of a temperature-sensitive channelopathy of peripheral neurons and to investigate the neural correlates of tonic neuropathic pain and relief in a single subject.
AbstractList Using a composite diagnostic-neuroimaging approach, this study shows the modulatory effects of pleasant cooling on pain-related cortical regions in a subject suffering from inherited erythromelalgia. We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Na v 1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design to assess her baseline erythromelalgia pain vs cooling relief. Robust activations of key pain, pain-affect, and reward-related centres were observed. This combined approach allowed us to confirm the presence of a temperature-sensitive channelopathy of peripheral neurons and to investigate the neural correlates of tonic neuropathic pain and relief in a single subject.
We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Na(v)1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design to assess her baseline erythromelalgia pain vs cooling relief. Robust activations of key pain, pain-affect, and reward-related centres were observed. This combined approach allowed us to confirm the presence of a temperature-sensitive channelopathy of peripheral neurons and to investigate the neural correlates of tonic neuropathic pain and relief in a single subject.
We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Na(v)1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design to assess her baseline erythromelalgia pain vs cooling relief. Robust activations of key pain, pain-affect, and reward-related centres were observed. This combined approach allowed us to confirm the presence of a temperature-sensitive channelopathy of peripheral neurons and to investigate the neural correlates of tonic neuropathic pain and relief in a single subject.We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Na(v)1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design to assess her baseline erythromelalgia pain vs cooling relief. Robust activations of key pain, pain-affect, and reward-related centres were observed. This combined approach allowed us to confirm the presence of a temperature-sensitive channelopathy of peripheral neurons and to investigate the neural correlates of tonic neuropathic pain and relief in a single subject.
Using a composite diagnostic-neuroimaging approach, this study shows the modulatory effects of pleasant cooling on pain-related cortical regions in a subject suffering from inherited erythromelalgia. We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Nav1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design to assess her baseline erythromelalgia pain vs cooling relief. Robust activations of key pain, pain-affect, and reward-related centres were observed. This combined approach allowed us to confirm the presence of a temperature-sensitive channelopathy of peripheral neurons and to investigate the neural correlates of tonic neuropathic pain and relief in a single subject.
Using a composite diagnostic-neuroimaging approach, this study shows the modulatory effects of pleasant cooling on pain-related cortical regions in a subject suffering from inherited erythromelalgia. We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Nav1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design to assess her baseline erythromelalgia pain vs cooling relief. Robust activations of key pain, pain-affect, and reward-related centres were observed. This combined approach allowed us to confirm the presence of a temperature-sensitive channelopathy of peripheral neurons and to investigate the neural correlates of tonic neuropathic pain and relief in a single subject.
Author Xie, Jingyi
Bennett, David L.H.
Segerdahl, Andrew R.
Paterson, Kathryn
Tracey, Irene
Ramirez, Juan D.
AuthorAffiliation Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), University of Oxford, Oxford, Oxfordshire, UK Wolfson Centre for Age-Related Disease, Kings College London, Hodgkin Building, Guys Campus, SE1 1UL London, UK
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– name: a Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), University of Oxford, Oxford, Oxfordshire, UK
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Issue 5
Keywords Erythromelalgia
Arterial spin labelling
FMRI
Neuropathic pain
Human
Temperature
Cooling
Hypersensitivity
Nuclear magnetic resonance imaging
Foot
Pain
Neuron
Sodium
Voltage
Mutation
Technique
Language English
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Copyright © 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
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SSID ssj0002229
Score 2.2122924
Snippet Using a composite diagnostic-neuroimaging approach, this study shows the modulatory effects of pleasant cooling on pain-related cortical regions in a subject...
We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Na(v)1.7. The patient reported...
SourceID pubmedcentral
proquest
pubmed
pascalfrancis
crossref
wolterskluwer
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1122
SubjectTerms Adult
Arterial spin labelling
Biological and medical sciences
Brain - physiopathology
Clinical Note
Erythromelalgia
Erythromelalgia - genetics
Erythromelalgia - physiopathology
Female
FMRI
Functional Neuroimaging - methods
Fundamental and applied biological sciences. Psychology
Humans
Illness and personality
Illness, stress and coping
NAV1.7 Voltage-Gated Sodium Channel
Neuralgia - genetics
Neuralgia - physiopathology
Neuropathic pain
Pleasure - physiology
Psychology and medicine
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Sensory Thresholds - physiology
Sodium Channels - genetics
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors
Spin Labels
Vertebrates: nervous system and sense organs
Title Imaging the neural correlates of neuropathic pain and pleasurable relief associated with inherited erythromelalgia in a single subject with quantitative arterial spin labelling
URI https://dx.doi.org/10.1016/j.pain.2011.12.012
https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00006396-201205000-00026
https://www.ncbi.nlm.nih.gov/pubmed/22365309
https://www.proquest.com/docview/1009131326
https://pubmed.ncbi.nlm.nih.gov/PMC3438450
Volume 153
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