Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy
Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern&...
Saved in:
| Published in | Allergy (Copenhagen) Vol. 64; no. 9; pp. 1333 - 1341 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Oxford, UK : Blackwell Publishing Ltd
01.09.2009
Blackwell Publishing Ltd Blackwell |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments. We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (Pinteraction = 0.004), itchy rash <12 mo (Pinteraction = 0.001) and dry cough at night in the past 12 months (<12 months) (Pinteraction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (Pinteraction = 0.006), rhinitis <12 mo (Pinteraction = 0.004), and marginally significant for ever hayfever (Pinteraction = 0.07), allergic eye symptoms <12 mo (Pinteraction = 0.09); their risk allele was G in Russians and A in Finns. An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. |
|---|---|
| AbstractList | Background:
Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between ‘Western’ and ‘Eastern’ environments.
Objectives:
We investigated associations between allergic diseases and
CD14
and
CC16
polymorphisms in Finnish
vs
Russian Karelian women.
Methods:
Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for
CD14
C‐159T and
CC16
A38G.
Results:
For both
CD14
C‐159T and
CC16
A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For
CD14
C‐159T, an interactive effect on ever itchy rash (
P
interaction
= 0.004), itchy rash <12 mo (
P
interaction
= 0.001) and dry cough at night in the past 12 months (<12 months) (
P
interaction
= 0.011) was found; the risk allele was C in Russians and T in Finns. For
CC16
A38G, an interaction was significant for ever rhinitis (
P
interaction
= 0.006), rhinitis <12 mo (
P
interaction
= 0.004), and marginally significant for ever hayfever (
P
interaction
= 0.07), allergic eye symptoms <12 mo (
P
interaction
= 0.09); their risk allele was G in Russians and A in Finns.
Conclusion:
An Eastern
vs
Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments.Objectives: We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women.Methods: Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G.Results: For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (Pinteraction = 0.004), itchy rash <12 mo (Pinteraction = 0.001) and dry cough at night in the past 12 months (<12 months) (Pinteraction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (Pinteraction = 0.006), rhinitis <12 mo (Pinteraction = 0.004), and marginally significant for ever hayfever (Pinteraction = 0.07), allergic eye symptoms <12 mo (Pinteraction = 0.09); their risk allele was G in Russians and A in Finns.Conclusion: An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. BACKGROUNDFinnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments.OBJECTIVESWe investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women.METHODSAdult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G.RESULTSFor both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (P(interaction) = 0.004), itchy rash <12 mo (P(interaction) = 0.001) and dry cough at night in the past 12 months (<12 months) (P(interaction) = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (P(interaction) = 0.006), rhinitis <12 mo (P(interaction) = 0.004), and marginally significant for ever hayfever (P(interaction) = 0.07), allergic eye symptoms <12 mo (P(interaction) = 0.09); their risk allele was G in Russians and A in Finns.CONCLUSIONAn Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments. We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (P(interaction) = 0.004), itchy rash <12 mo (P(interaction) = 0.001) and dry cough at night in the past 12 months (<12 months) (P(interaction) = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (P(interaction) = 0.006), rhinitis <12 mo (P(interaction) = 0.004), and marginally significant for ever hayfever (P(interaction) = 0.07), allergic eye symptoms <12 mo (P(interaction) = 0.09); their risk allele was G in Russians and A in Finns. An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments. We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (Pinteraction = 0.004), itchy rash <12 mo (Pinteraction = 0.001) and dry cough at night in the past 12 months (<12 months) (Pinteraction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (Pinteraction = 0.006), rhinitis <12 mo (Pinteraction = 0.004), and marginally significant for ever hayfever (Pinteraction = 0.07), allergic eye symptoms <12 mo (Pinteraction = 0.09); their risk allele was G in Russians and A in Finns. An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between ‘Western’ and ‘Eastern’ environments. Objectives: We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Methods: Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C‐159T and CC16 A38G. Results: For both CD14 C‐159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C‐159T, an interactive effect on ever itchy rash (Pinteraction = 0.004), itchy rash <12 mo (Pinteraction = 0.001) and dry cough at night in the past 12 months (<12 months) (Pinteraction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (Pinteraction = 0.006), rhinitis <12 mo (Pinteraction = 0.004), and marginally significant for ever hayfever (Pinteraction = 0.07), allergic eye symptoms <12 mo (Pinteraction = 0.09); their risk allele was G in Russians and A in Finns. Conclusion: An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyze genetic and allergic disease interactions between 'Western' and 'Eastern' environments. We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash ( P interaction = 0.004), itchy rash <12 mo ( P interaction = 0.001) and dry cough at night in the past 12 months (<12 months) ( P interaction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis ( P interaction = 0.006), rhinitis <12 mo ( P interaction = 0.004), and marginally significant for ever hayfever ( P interaction = 0.07), allergic eye symptoms <12 mo ( P interaction = 0.09); their risk allele was G in Russians and A in Finns. An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. [PUBLICATION ABSTRACT] |
| Author | Zhang, G Pekkarinen, P Haahtela, T Laatikainen, T Vartiainen, E Le Souëf, P.N von Hertzen, L Goldblatt, J Hayden, C.M Khoo, S.-K Mäkelä, M |
| Author_xml | – sequence: 1 fullname: Zhang, G – sequence: 2 fullname: Khoo, S.-K – sequence: 3 fullname: Laatikainen, T – sequence: 4 fullname: Pekkarinen, P – sequence: 5 fullname: Vartiainen, E – sequence: 6 fullname: von Hertzen, L – sequence: 7 fullname: Hayden, C.M – sequence: 8 fullname: Goldblatt, J – sequence: 9 fullname: Mäkelä, M – sequence: 10 fullname: Haahtela, T – sequence: 11 fullname: Le Souëf, P.N |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21893403$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19222419$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkc2PEyEYh4lZ43ZX_wUlJuqplRdmYDjsYVM_Y5M96J4JZaDSMDDCVLf_vXTbrIkHIwc-wvN74c1zgc5iihYhDGQBdbzdLoDJbi6lbBeUELkgdeaLu0do9nBxhmYESDtvWtado4tStoQQQSV5gs5BUkobkDOUb8YxFT9ZvLHR4vUe2_jT5xQHGyfs42SzNpNPsdQD_qKzDV5jlzJevoMG69jj5RI4Lj5ugsVxZ4JNk-8tHlPYDymP330Zyj2oQ7B5s3-KHjsdin12Wi_R7Yf335af5qubj5-X16u5aRnhcxDa9cAbR6HvbcNAEtBCCssYb4XretE43TTMQMcF69YSnBa9MM7YvnemZ5fozbHumNOPnS2TGnwxNgQdbdoVJVhDWhCtrOTrf5KUdJI3lFbw5V_gNu1yrF0okFxCJwSvUHeETE6lZOvUmP2g814BUQd9aqsOltTBkjroU_f61F2NPj_V360H2_8JnnxV4NUJ0MXo4LKOxpcHjkIna1escldH7pcPdv_fH1DXq9VhV_Mvjnmnk9KbXN-4_UoJMAKccxAd-w2cnMCM |
| CODEN | LLRGDY |
| CitedBy_id | crossref_primary_10_1111_pai_12612 crossref_primary_10_3389_falgy_2023_1152927 crossref_primary_10_1111_j_1398_9995_2009_02145_x crossref_primary_10_1111_j_1440_1843_2009_01700_x crossref_primary_10_1016_j_jaci_2012_01_047 crossref_primary_10_1111_j_1752_699X_2010_00213_x crossref_primary_10_4168_aair_2014_6_4_350 crossref_primary_10_1016_S0300_2896_10_70005_3 crossref_primary_10_1016_j_gene_2013_06_049 crossref_primary_10_3402_ecrj_v2_27803 crossref_primary_10_1038_srep33240 crossref_primary_10_1111_cea_12527 crossref_primary_10_1111_j_1399_3038_2011_01186_x crossref_primary_10_1128_IAI_00261_12 crossref_primary_10_1111_j_1365_2222_2011_03844_x crossref_primary_10_1016_j_aller_2012_05_011 crossref_primary_10_1016_j_jaci_2012_04_052 crossref_primary_10_1097_ACI_0b013e32834a9676 crossref_primary_10_1111_j_1365_2222_2010_03679_x crossref_primary_10_1177_03946320110240S409 crossref_primary_10_1016_j_opresp_2023_100245 crossref_primary_10_1080_19338244_2011_638950 crossref_primary_10_1186_s12931_022_02211_6 crossref_primary_10_1111_all_13763 crossref_primary_10_1111_j_1365_2222_2009_03391_x crossref_primary_10_1111_j_1398_9995_2009_02246_x crossref_primary_10_2217_pme_10_75 crossref_primary_10_1183_13993003_01228_2017 crossref_primary_10_1097_ACI_0b013e32833653d7 crossref_primary_10_1080_02770903_2021_1978483 crossref_primary_10_3109_07853890_2010_481678 crossref_primary_10_1016_j_waojou_2023_100857 crossref_primary_10_1038_jhg_2009_97 |
| Cites_doi | 10.1007/s11882-006-0047-y 10.1164/rccm.200509-1380OC 10.1136/thx.2004.028449 10.1159/000091167 10.1111/j.1365-2222.2008.03102.x 10.1146/annurev.med.56.062904.144908 10.1186/1465-9921-4-14 10.1016/j.jaci.2005.02.006 10.1111/j.1398-9995.2008.01804.x 10.1016/j.jaci.2006.07.007 10.1161/01.CIR.99.25.3218 10.1016/j.jaci.2005.03.001 10.1111/j.1462-2920.2008.01723.x 10.1016/j.jaci.2005.05.003 10.1093/hmg/11.20.2463 10.1164/rccm.2604006 10.1007/s00251-005-0778-2 10.1165/ajrcmb.20.5.3494 10.1067/mai.2003.180 10.1067/mai.2002.123307 10.1111/j.1398-9995.2006.01281.x 10.1097/ACI.0b013e328012ce39 10.1016/S0140-6736(97)01468-2 10.1046/j.1398-9995.2003.00433.x 10.1183/09031936.00123206 10.1097/01.all.0000244790.18486.be 10.1111/j.1365-2249.2007.03333.x 10.1093/ije/30.5.1035 10.1007/s10654-007-9217-z 10.1183/09031936.02.00254202 10.1111/j.1365-2222.2005.02206.x 10.1111/j.1365-2222.2005.02339.x 10.1111/j.1399-3038.1997.tb00156.x 10.1038/sj.gene.6364284 10.1016/j.jaci.2005.07.028 10.1164/rccm.200509-1367OC 10.1086/429418 10.1086/321191 10.1136/jmg.35.6.463 10.1046/j.1365-2222.2003.01549.x 10.4049/jimmunol.167.10.5838 10.1016/j.jaci.2006.06.015 10.1111/j.1398-9995.2006.01249.x 10.1016/j.iac.2005.09.001 10.1164/rccm.200302-278OC 10.1086/512133 |
| ContentType | Journal Article |
| Copyright | 2009 John Wiley & Sons A/S 2009 INIST-CNRS Journal compilation © 2009 Blackwell Munksgaard |
| Copyright_xml | – notice: 2009 John Wiley & Sons A/S – notice: 2009 INIST-CNRS – notice: Journal compilation © 2009 Blackwell Munksgaard |
| DBID | FBQ IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 H94 K9. 7TM 8FD FR3 P64 RC3 7X8 |
| DOI | 10.1111/j.1398-9995.2009.02006.x |
| DatabaseName | AGRIS Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Immunology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Nucleic Acids Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Genetics Abstracts Technology Research Database Nucleic Acids Abstracts Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | CrossRef Genetics Abstracts MEDLINE - Academic MEDLINE AIDS and Cancer Research Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1398-9995 |
| EndPage | 1341 |
| ExternalDocumentID | 1833401391 10_1111_j_1398_9995_2009_02006_x 19222419 21893403 ALL2006 US201301666178 |
| Genre | article Journal Article |
| GeographicLocations | Karelia Eurasia Russian Federation Finland Russia |
| GeographicLocations_xml | – name: Finland – name: Russia |
| GroupedDBID | .3N .GA .GJ .Y3 05W 0R~ 10A 1OB 1OC 23M 24P 2WC 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8F7 8UM 930 A01 A03 AAESR AAEVG AAHHS AAKAS AANLZ AAONW AASGY AAVGM AAXRX AAZKR ABCQN ABCUV ABEML ABHUG ABJNI ABLJU ABOCM ABPTK ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXME ACXQS ADAWD ADBBV ADBTR ADDAD ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZCM ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFRAH AFVGU AFZJQ AGJLS AHMBA AIACR AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB AOETA ATUGU AZBYB AZFZN AZVAB BAFTC BAWUL BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DC6 DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM E3Z EBS EJD EMOBN ESX EX3 F00 F01 F04 F5P FBQ FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OK1 OVD P2P P2W P2X P2Z P4B P4D P6G PALCI PQQKQ Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ TEORI TR2 UB1 V9Y W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR XG1 Y6R ZGI ZXP ZZTAW ~IA ~KM ~WT AHBTC AHEFC AITYG HGLYW OIG WIN AAPBV IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 H94 K9. 7TM 8FD FR3 P64 RC3 7X8 |
| ID | FETCH-LOGICAL-c5306-17afd164f21dde431901a797e33657f8d74fa443c186738b91fa7d7cfceddfcd3 |
| IEDL.DBID | DR2 |
| ISSN | 0105-4538 |
| IngestDate | Sat Aug 17 01:15:13 EDT 2024 Fri Aug 16 09:39:59 EDT 2024 Thu Oct 10 20:43:32 EDT 2024 Fri Aug 23 01:12:29 EDT 2024 Sat Sep 28 07:54:30 EDT 2024 Sun Oct 22 16:07:41 EDT 2023 Sat Aug 24 00:54:45 EDT 2024 Wed Dec 27 19:07:24 EST 2023 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Keywords | Lung disease Allergy Immunopathology genetic risk factors Genetic variability Dermatology Respiratory disease Genotype Exposure Epidemiology Asthma Immunology Genotype environment interaction Risk factor Bronchus disease Environment Genetics Obstructive pulmonary disease Single nucleotide polymorphism respiratory diseases environmental exposures |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5306-17afd164f21dde431901a797e33657f8d74fa443c186738b91fa7d7cfceddfcd3 |
| Notes | http://dx.doi.org/10.1111/j.1398-9995.2009.02006.x ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1398-9995.2009.02006.x |
| PMID | 19222419 |
| PQID | 196918776 |
| PQPubID | 34098 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_734051759 proquest_miscellaneous_20896422 proquest_journals_196918776 crossref_primary_10_1111_j_1398_9995_2009_02006_x pubmed_primary_19222419 pascalfrancis_primary_21893403 wiley_primary_10_1111_j_1398_9995_2009_02006_x_ALL2006 fao_agris_US201301666178 |
| PublicationCentury | 2000 |
| PublicationDate | September 2009 |
| PublicationDateYYYYMMDD | 2009-09-01 |
| PublicationDate_xml | – month: 09 year: 2009 text: September 2009 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: Oxford – name: Denmark – name: Zurich |
| PublicationTitle | Allergy (Copenhagen) |
| PublicationTitleAlternate | Allergy |
| PublicationYear | 2009 |
| Publisher | Oxford, UK : Blackwell Publishing Ltd Blackwell Publishing Ltd Blackwell |
| Publisher_xml | – name: Oxford, UK : Blackwell Publishing Ltd – name: Blackwell Publishing Ltd – name: Blackwell |
| References | 2001; 167 2004; 169 2002; 19 2000; 67 1997; 350 2005; 115 2005; 116 2002; 11 2006; 174 2006; 7 2006; 173 2006; 6 1999; 20 2008; 10 2005; 60 2007; 30 2006; 118 2006; 117 2006; 139 2003; 111 2003; 33 2005; 25 1997; 8 2004; 59 1986 2003; 4 2008; 23 1999; 99 2007; 80 2007; 7 2005; 76 2008; 63 2007; 62 2002; 109 2007; 1 2005; 56 2001; 30 2005; 57 2005; 35 1998; 35 2009; 39 e_1_2_5_26_2 e_1_2_5_27_2 e_1_2_5_48_2 e_1_2_5_24_2 e_1_2_5_25_2 e_1_2_5_46_2 e_1_2_5_22_2 e_1_2_5_45_2 e_1_2_5_23_2 e_1_2_5_44_2 e_1_2_5_20_2 e_1_2_5_43_2 e_1_2_5_21_2 e_1_2_5_42_2 e_1_2_5_28_2 e_1_2_5_41_2 e_1_2_5_40_2 e_1_2_5_14_2 e_1_2_5_37_2 e_1_2_5_13_2 e_1_2_5_38_2 e_1_2_5_9_2 e_1_2_5_16_2 e_1_2_5_35_2 e_1_2_5_8_2 e_1_2_5_15_2 e_1_2_5_36_2 e_1_2_5_7_2 e_1_2_5_10_2 e_1_2_5_33_2 e_1_2_5_6_2 e_1_2_5_34_2 e_1_2_5_5_2 e_1_2_5_12_2 e_1_2_5_31_2 e_1_2_5_4_2 e_1_2_5_11_2 e_1_2_5_32_2 e_1_2_5_3_2 e_1_2_5_2_2 e_1_2_5_18_2 e_1_2_5_17_2 e_1_2_5_39_2 e_1_2_5_19_2 Baldini M (e_1_2_5_29_2) 1999; 20 e_1_2_5_30_2 Rothman K (e_1_2_5_47_2) 1986 |
| References_xml | – volume: 8 start-page: 161 year: 1997 end-page: 176 article-title: Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the International Study of Asthma and Allergies in Childhood (ISAAC) publication-title: Pediatr Allergy Immunol – volume: 174 start-page: 386 year: 2006 end-page: 392 article-title: Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment publication-title: Am J Respir Crit Care Med – volume: 59 start-page: 121 year: 2004 end-page: 123 article-title: Asthma and atopy – the price of affluence? publication-title: Allergy – volume: 169 start-page: 615 year: 2004 end-page: 622 article-title: Age‐specific relationship between CD14 and atopy in a cohort assessed from age 8 to 25 years publication-title: Am J Respir Crit Care Med – start-page: 147 year: 1986 end-page: 150 – volume: 35 start-page: 1272 year: 2005 end-page: 1278 article-title: Bacterial and fungal agents in house dust and wheeze in children: the PARSIFAL study publication-title: Clin Exp Allergy – volume: 10 start-page: 3317 year: 2008 end-page: 3325 article-title: Predominance of Gram‐positive bacteria in house dust in the low‐allergy risk Russian Karelia publication-title: Environ Microbiol – volume: 80 start-page: 531 year: 2007 end-page: 538 article-title: No gene is an island: the flip‐flop phenomenon publication-title: Am J Hum Genet – volume: 6 start-page: 317 year: 2006 end-page: 322 article-title: Variations in genetic influences on the development of asthma throughout childhood, adolescence and early adult life publication-title: Curr Opin Allergy Clin Immunol – volume: 1 start-page: 47 year: 2007 end-page: 52 article-title: Allergic sensitization and microbial load – a comparison between Finland and Russian Karelia publication-title: Clin Exp Immunol – volume: 25 start-page: 709 year: 2005 end-page: 721 article-title: Gene‐environment interactions in asthma and allergies: a new paradigm to understand disease causation publication-title: Immunol Allergy Clin North Am – volume: 19 start-page: 158 year: 2002 end-page: 171 article-title: The bidirectional capacity of bacterial antigens to modulate allergy and asthma publication-title: Eur Respir J – volume: 118 start-page: 658 year: 2006 end-page: 665 article-title: Association between farm exposure and atopy, according to the CD14 C‐159T polymorphism publication-title: J Allergy Clin Immunol – volume: 173 start-page: 617 year: 2006 end-page: 622 article-title: Acute asthma in children: relationships among and genotypes, plasma levels, and severity publication-title: Am J Respir Crit Care Med – volume: 118 start-page: 851 year: 2006 end-page: 857 article-title: Gene‐environment interactions with CD14 C‐260T and their relationship to total serum IgE levels in adults publication-title: J Allergy Clin Immunol – volume: 111 start-page: 515 year: 2003 end-page: 519 article-title: Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children publication-title: J Allergy Clin Immunol – volume: 350 start-page: 1015 year: 1997 end-page: 1020 article-title: Epidemiology of childhood asthma publication-title: Lancet – volume: 23 start-page: 123 year: 2008 end-page: 133 article-title: Comparison of allergic diseases, symptoms and respiratory infections between Finnish and Russian school children publication-title: Eur J Epidemiol – volume: 116 start-page: 601 year: 2005 end-page: 607 article-title: Opposite effects of CD 14/‐260 on serum IgE levels in children raised in different environments publication-title: J Allergy Clin Immunol – volume: 117 start-page: 151 year: 2006 end-page: 157 article-title: Growing disparities in atopy between the Finns and the Russians: a comparison of 2 generations publication-title: J Allergy Clin Immunol – volume: 39 start-page: 62 year: 2009 end-page: 71 article-title: Cross sectional and longitudinal analysis of the contribution of the A38G polymorphism in the secretoglobin 1A1 (SCGB1A1) gene to the asthma phenotype in the Perth Infant Asthma Follow‐up Cohort publication-title: Clin Exp Allergy – volume: 62 start-page: 288 year: 2007 end-page: 292 article-title: Microbial content of drinking water in Finnish and Russian Karelia – implications for atopy prevalence publication-title: Allergy – volume: 35 start-page: 473 year: 2005 end-page: 478 article-title: Gene profiling reveals decreased expression of uteroglobin and other anti‐inflammatory genes in nasal fluid cells from patients with intermittent allergic rhinitis publication-title: Clin Exp Allergy – volume: 7 start-page: 95 year: 2006 end-page: 100 article-title: Asthma genetics 2006: the long and winding road to gene discovery publication-title: Genes Immun – volume: 167 start-page: 5838 year: 2001 end-page: 5844 article-title: A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity publication-title: J Immunol – volume: 99 start-page: 3218 year: 1999 end-page: 3220 article-title: C(‐260)‐‐>T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction publication-title: Circulation – volume: 63 start-page: 1411 year: 2008 end-page: 1417 article-title: Does the relationship between IgE and the CD14 gene depend on ethnicity? publication-title: Allergy – volume: 115 start-page: 1203 year: 2005 end-page: 1209 article-title: Evaluation of the CD14/‐260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study publication-title: J Allergy Clin Immunol – volume: 11 start-page: 2463 year: 2002 end-page: 2468 article-title: Epistasis: what it means, what it doesn’t mean, and statistical methods to detect it in humans publication-title: Hum Mol Genet – volume: 109 start-page: 643 year: 2002 end-page: 648 article-title: Allergic diseases, skin prick test responses, and IgE levels in North Karelia, Finland, and the Republic of Karelia, Russia publication-title: J Allergy Clin Immunol – volume: 35 start-page: 463 year: 1998 end-page: 467 article-title: A polymorphism of the CC16 gene is associated with an increased risk of asthma publication-title: J Med Genet – volume: 4 start-page: 14 year: 2003 article-title: Association studies for asthma and atopic diseases: a comprehensive review of the literature publication-title: Respir Res – volume: 76 start-page: 696 year: 2005 end-page: 704 article-title: Gene‐environment interaction effects on the development of immune responses in the 1st year of life publication-title: Am J Hum Genet – volume: 62 start-page: 281 year: 2007 end-page: 287 article-title: A disparity in the association of asthma, rhinitis, and eczema with allergen‐specific IgE between Finnish and Russian Karelia publication-title: Allergy – volume: 174 start-page: 365 year: 2006 end-page: 366 article-title: A glitch in the switch? Of endotoxin, CD14, and allergy publication-title: Am J Respir Crit Care Med – volume: 20 start-page: 976 year: 1999 end-page: 983 article-title: A Polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E publication-title: Am J Respir Cell Mol Biol – volume: 33 start-page: 166 year: 2003 end-page: 169 article-title: Evaluation of the CD14 C‐159 T polymorphism in the German Multicenter Allergy Study cohort publication-title: Clin Exp Allergy – volume: 57 start-page: 25 year: 2005 end-page: 32 article-title: Association between asthma‐related phenotypes and the CC16 A38G polymorphism in an unselected population of young adult Danes publication-title: Immunogenetics – volume: 115 start-page: 1056 year: 2005 end-page: 1062 article-title: Polymorphisms in the 5′ region of the CD14 gene are associated with eczema in young children publication-title: J Allergy Clin Immunol – volume: 6 start-page: 103 year: 2006 end-page: 111 article-title: Gene by environment interaction in asthma publication-title: Curr Allergy Asthma Rep – volume: 139 start-page: 217 year: 2006 end-page: 224 article-title: CD14 promoter polymorphisms in atopic families: implications for modulated allergen‐specific immunoglobulin E and G1 responses publication-title: Int Arch Allergy Immunol – volume: 60 start-page: 211 year: 2005 end-page: 214 article-title: The CD14 C‐159T polymorphism is not associated with asthma or asthma severity in an Australian adult population publication-title: Thorax – volume: 30 start-page: 48 year: 2007 end-page: 55 article-title: Beta2‐Adrenoceptor polymorphisms and asthma phenotypes: interactions with passive smoking publication-title: Eur Respir J – volume: 30 start-page: 1035 year: 2001 end-page: 1040 article-title: Sample size determination for studies of gene‐environment interaction publication-title: Int J Epidemiol – volume: 67 start-page: 1154 year: 2000 end-page: 1162 article-title: A second‐generation genomewide screen for asthma‐susceptibility alleles in a founder population publication-title: Am J Hum Genet – volume: 56 start-page: 383 year: 2005 end-page: 400 article-title: Gene‐environment interactions in asthma and other respiratory diseases publication-title: Annu Rev Med – volume: 7 start-page: 75 year: 2007 end-page: 82 article-title: Gene‐environmental interaction in asthma publication-title: Curr Opin Allergy Clin Immunol – ident: e_1_2_5_34_2 doi: 10.1007/s11882-006-0047-y – ident: e_1_2_5_8_2 doi: 10.1164/rccm.200509-1380OC – ident: e_1_2_5_18_2 doi: 10.1136/thx.2004.028449 – ident: e_1_2_5_17_2 doi: 10.1159/000091167 – ident: e_1_2_5_26_2 doi: 10.1111/j.1365-2222.2008.03102.x – ident: e_1_2_5_2_2 doi: 10.1146/annurev.med.56.062904.144908 – ident: e_1_2_5_5_2 doi: 10.1186/1465-9921-4-14 – ident: e_1_2_5_21_2 doi: 10.1016/j.jaci.2005.02.006 – ident: e_1_2_5_19_2 doi: 10.1111/j.1398-9995.2008.01804.x – ident: e_1_2_5_42_2 doi: 10.1016/j.jaci.2006.07.007 – ident: e_1_2_5_37_2 doi: 10.1161/01.CIR.99.25.3218 – ident: e_1_2_5_23_2 doi: 10.1016/j.jaci.2005.03.001 – ident: e_1_2_5_31_2 doi: 10.1111/j.1462-2920.2008.01723.x – ident: e_1_2_5_7_2 doi: 10.1016/j.jaci.2005.05.003 – ident: e_1_2_5_28_2 doi: 10.1093/hmg/11.20.2463 – ident: e_1_2_5_35_2 doi: 10.1164/rccm.2604006 – ident: e_1_2_5_25_2 doi: 10.1007/s00251-005-0778-2 – volume: 20 start-page: 976 year: 1999 ident: e_1_2_5_29_2 article-title: A Polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E publication-title: Am J Respir Cell Mol Biol doi: 10.1165/ajrcmb.20.5.3494 contributor: fullname: Baldini M – ident: e_1_2_5_44_2 doi: 10.1067/mai.2003.180 – ident: e_1_2_5_12_2 doi: 10.1067/mai.2002.123307 – ident: e_1_2_5_41_2 doi: 10.1111/j.1398-9995.2006.01281.x – ident: e_1_2_5_6_2 doi: 10.1097/ACI.0b013e328012ce39 – ident: e_1_2_5_4_2 doi: 10.1016/S0140-6736(97)01468-2 – ident: e_1_2_5_9_2 doi: 10.1046/j.1398-9995.2003.00433.x – ident: e_1_2_5_43_2 doi: 10.1183/09031936.00123206 – ident: e_1_2_5_14_2 doi: 10.1097/01.all.0000244790.18486.be – ident: e_1_2_5_40_2 doi: 10.1111/j.1365-2249.2007.03333.x – ident: e_1_2_5_48_2 doi: 10.1093/ije/30.5.1035 – ident: e_1_2_5_13_2 doi: 10.1007/s10654-007-9217-z – ident: e_1_2_5_33_2 doi: 10.1183/09031936.02.00254202 – ident: e_1_2_5_45_2 doi: 10.1111/j.1365-2222.2005.02206.x – ident: e_1_2_5_30_2 doi: 10.1111/j.1365-2222.2005.02339.x – start-page: 147 volume-title: Modern epidemiology year: 1986 ident: e_1_2_5_47_2 contributor: fullname: Rothman K – ident: e_1_2_5_10_2 doi: 10.1111/j.1399-3038.1997.tb00156.x – ident: e_1_2_5_16_2 doi: 10.1038/sj.gene.6364284 – ident: e_1_2_5_11_2 doi: 10.1016/j.jaci.2005.07.028 – ident: e_1_2_5_22_2 doi: 10.1164/rccm.200509-1367OC – ident: e_1_2_5_32_2 doi: 10.1086/429418 – ident: e_1_2_5_39_2 doi: 10.1086/321191 – ident: e_1_2_5_24_2 doi: 10.1136/jmg.35.6.463 – ident: e_1_2_5_38_2 doi: 10.1046/j.1365-2222.2003.01549.x – ident: e_1_2_5_36_2 doi: 10.4049/jimmunol.167.10.5838 – ident: e_1_2_5_20_2 doi: 10.1016/j.jaci.2006.06.015 – ident: e_1_2_5_27_2 doi: 10.1111/j.1398-9995.2006.01249.x – ident: e_1_2_5_3_2 doi: 10.1016/j.iac.2005.09.001 – ident: e_1_2_5_15_2 doi: 10.1164/rccm.200302-278OC – ident: e_1_2_5_46_2 doi: 10.1086/512133 |
| SSID | ssj0007290 |
| Score | 2.171864 |
| Snippet | Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the... Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic... Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic... Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic... BACKGROUNDFinnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group,... |
| SourceID | proquest crossref pubmed pascalfrancis wiley fao |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 1333 |
| SubjectTerms | Adult Alleles Allergies asthma Biological and medical sciences Chronic obstructive pulmonary disease, asthma Dermatology Environment environmental exposures Female Finland - ethnology Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Frequency - genetics genetic risk factors Genetics Genetics, Population Genotype Humans Hypersensitivity - epidemiology Hypersensitivity - genetics Hypersensitivity - immunology Lipopolysaccharide Receptors - genetics Lipopolysaccharide Receptors - immunology Logistic Models Medical sciences Minority & ethnic groups Pneumology Polymorphism, Single Nucleotide - genetics Polymorphism, Single Nucleotide - immunology Prevalence respiratory diseases respiratory tract diseases Risk factors Russia - epidemiology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Uteroglobin - genetics Uteroglobin - immunology Women |
| Title | Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1398-9995.2009.02006.x https://www.ncbi.nlm.nih.gov/pubmed/19222419 https://www.proquest.com/docview/196918776 https://search.proquest.com/docview/20896422 https://search.proquest.com/docview/734051759 |
| Volume | 64 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5BD4gLUF4NpcUHrqk2ceLHsVqoqqoFCVipN8uJ7WrVbbLa7Eosv56ZJLttUJEqxC1RHCe2Z-zPM-NvAD7KkZRWJSHW1vKYMHmshZSxF17kqSaMTnbIiy_idJKdXeaXffwTnYXp-CG2BjfSjHa-JgW3RTNUcq5RWbXOe9rJ1rNAeJJ49QgffbtlkpK9uQXhRJyhkg-Deu6taLBSPQ62prhJ22DXhS7nxX2gdIhx20Xq5Dlcb5rXxaZcH62WxVH56w_mx__T_hfwrMey7LgTvl145KuX8OSi99a_gsXXeRsT5hlKqWfFmt05VseIqGLRHato8IbRsbTZ1DJE0Wz8KcmYrRwbjxPByJwx86wi6uV6OXWezevZ-qZGEZk2N01bkFLCLK7Wr2Fy8vnH-DTuczzEZc4pBZC0weGWLaQJTrSIZhCfWKml51zkMigns2CzjJdEvMdVoZNgpZNlKL1zoXT8DexUdeX3gHGrfIHy5QkkapcWiG2ECslIuaCkLCNINuNp5h2Vh7mzBcLONNSZlJhTm7Yzzc8I9nDgjb3CGddMvqfk5yVHayJVBIcDadjWiaBJ82zEI9jfiIfpJ4bGEBtRgn8jIviwfYoaTW4aW_l61eD3lcZdYRoB-0sJidXniPt0BG87sbttkE4JlOET0QrPg1tqjs_P6erdv764D087TxvF372HneVi5Q8QsC2Lw1YVfwMlJi4E |
| link.rule.ids | 315,786,790,1382,27955,27956,46327,46751 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fb5swED5tnbTtpfu9snatH_ZKFTBg_Filq9Iu6aStkfpmGWxXUVOIQiIt_et3ByQtVSdN095AGIOP-8znu_MdwBfRE0KngfOl1twnTu7LRAjfJjaJQ0kcneyQo_NkMI7OLuPLthwQ7YVp8kNsDG6EjHq-JoCTQbqLci4RrVLGbd7J2rWAhPIZoj8mlB7_uMslJVqDCxIKP0KYd8N6Hu2p86966nRJkZO6QuG5purFY7S0y3Lr39TJK5iuB9hEp1wfLhfZYX77IPfjf5LAa9hu6Sw7avTvDTyxxVt4Pmod9u9g_n1Wh4VZhopqWbZi93bWMcpVMW92VlR4wmhn2nSiGRJp1j8OIqYLw_r9IGFk0ZhaVlD25XIxMZbNyunqpkQtmVQ3Vd2QqsLMr1bvYXzy9aI_8NsyD34ec6oCJLQzuGpzYYBzLRIapChaSGE5T2LhUiMip6OI55R7j6eZDJwWRuQut8a43PAPsFWUhd0BxnVqM1QxSzxRmjBDepOkLuilxqVC5B4E6w-qZk02D3VvFYTCVCRMqs0pVS1M9cuDHfzySl_hpKvGP0Ny9ZKvNRCpB_sdddj0ibxJ8qjHPdhd64dq54ZKUUKiAN8m8eBgcxVBTZ4aXdhyWeHzU4kLw9AD9ocWAruPkfpJDz42enc3IBkSL8MrSa09fz1SdTQc0tGnf73xAF4MLkZDNTw9_7YLLxvHG4Xj7cHWYr60n5G_LbL9Gpe_ARmPMiQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fb9MwED7BkCZeGL-XDTY_8JqpiRM7fpxaqgHdQEClvVlObE_VuqRqWony13OXpN2KhoQQb4niOPH5zv7sO38H8E72pDRZ5ENlDA8Jk4dKSBk64UQaK8LotA95fiHOxsnHy_Syi3-iszAtP8Rmw40soxmvycBn1m8bOVdorEqlHe1k41lAPPkoETymhdjg6y2VlOz2WxBPhAla-XZUz701bU1VD72pKHDS1Cg73ya9uA-VboPcZpYa7sH1un1tcMr1yXKRnxQ_f6N-_D8CeApPOjDLTlvtewYPXPkcds87d_0LmH-eNUFhjqGaOpav2J1zdYyYKubtuYoabxidS5tODEMYzfqDKGGmtKzfjwSj_YypYyVxL1eLiXVsVk1XNxXqyKS-qZuClBNmfrV6CePh--_9s7BL8hAWKaccQNJ4i2s2H0c40iKcQYBipJKOc5FKn1mZeJMkvCDmPZ7lKvJGWln4wlnrC8tfwU5ZlW4fGDeZy1HBHKFEZeMcwY3IfNTLrM-kLAKI1v2pZy2Xh76zBkJhahImZeZUuhGm_hHAPna8Nlc45Orxt5gcveRpjWQWwNGWNmzqRNSkeNLjARyu1UN3I0OtiY4owr8RARxvnqJJk5_GlK5a1vj9TOGyMA6A_aGExOpTBH4qgNet2t02SMWEyvCJaJTnr1uqT0cjujr41xePYffLYKhHHy4-HcLj1utGsXhvYGcxX7q3CN4W-VFjlb8AQ-Ew0w |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Opposite+gene+by+environment+interactions+in+Karelia+for+CD14+and+CC16+single+nucleotide+polymorphisms+and+allergy&rft.jtitle=Allergy+%28Copenhagen%29&rft.au=Zhang%2C+G&rft.au=Khoo%2C+S-K&rft.au=Laatikainen%2C+T&rft.au=Pekkarinen%2C+P&rft.date=2009-09-01&rft.eissn=1398-9995&rft.volume=64&rft.issue=9&rft.spage=1333&rft.epage=1341&rft_id=info:doi/10.1111%2Fj.1398-9995.2009.02006.x&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0105-4538&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0105-4538&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0105-4538&client=summon |