Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy
Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern&...
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Published in | Allergy (Copenhagen) Vol. 64; no. 9; pp. 1333 - 1341 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Oxford, UK
Oxford, UK : Blackwell Publishing Ltd
01.09.2009
Blackwell Publishing Ltd Blackwell |
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Abstract | Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments. We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (Pinteraction = 0.004), itchy rash <12 mo (Pinteraction = 0.001) and dry cough at night in the past 12 months (<12 months) (Pinteraction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (Pinteraction = 0.006), rhinitis <12 mo (Pinteraction = 0.004), and marginally significant for ever hayfever (Pinteraction = 0.07), allergic eye symptoms <12 mo (Pinteraction = 0.09); their risk allele was G in Russians and A in Finns. An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. |
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AbstractList | Background:
Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between ‘Western’ and ‘Eastern’ environments.
Objectives:
We investigated associations between allergic diseases and
CD14
and
CC16
polymorphisms in Finnish
vs
Russian Karelian women.
Methods:
Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for
CD14
C‐159T and
CC16
A38G.
Results:
For both
CD14
C‐159T and
CC16
A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For
CD14
C‐159T, an interactive effect on ever itchy rash (
P
interaction
= 0.004), itchy rash <12 mo (
P
interaction
= 0.001) and dry cough at night in the past 12 months (<12 months) (
P
interaction
= 0.011) was found; the risk allele was C in Russians and T in Finns. For
CC16
A38G, an interaction was significant for ever rhinitis (
P
interaction
= 0.006), rhinitis <12 mo (
P
interaction
= 0.004), and marginally significant for ever hayfever (
P
interaction
= 0.07), allergic eye symptoms <12 mo (
P
interaction
= 0.09); their risk allele was G in Russians and A in Finns.
Conclusion:
An Eastern
vs
Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments.Objectives: We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women.Methods: Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G.Results: For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (Pinteraction = 0.004), itchy rash <12 mo (Pinteraction = 0.001) and dry cough at night in the past 12 months (<12 months) (Pinteraction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (Pinteraction = 0.006), rhinitis <12 mo (Pinteraction = 0.004), and marginally significant for ever hayfever (Pinteraction = 0.07), allergic eye symptoms <12 mo (Pinteraction = 0.09); their risk allele was G in Russians and A in Finns.Conclusion: An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. BACKGROUNDFinnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments.OBJECTIVESWe investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women.METHODSAdult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G.RESULTSFor both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (P(interaction) = 0.004), itchy rash <12 mo (P(interaction) = 0.001) and dry cough at night in the past 12 months (<12 months) (P(interaction) = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (P(interaction) = 0.006), rhinitis <12 mo (P(interaction) = 0.004), and marginally significant for ever hayfever (P(interaction) = 0.07), allergic eye symptoms <12 mo (P(interaction) = 0.09); their risk allele was G in Russians and A in Finns.CONCLUSIONAn Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments. We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (P(interaction) = 0.004), itchy rash <12 mo (P(interaction) = 0.001) and dry cough at night in the past 12 months (<12 months) (P(interaction) = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (P(interaction) = 0.006), rhinitis <12 mo (P(interaction) = 0.004), and marginally significant for ever hayfever (P(interaction) = 0.07), allergic eye symptoms <12 mo (P(interaction) = 0.09); their risk allele was G in Russians and A in Finns. An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments. We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (Pinteraction = 0.004), itchy rash <12 mo (Pinteraction = 0.001) and dry cough at night in the past 12 months (<12 months) (Pinteraction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (Pinteraction = 0.006), rhinitis <12 mo (Pinteraction = 0.004), and marginally significant for ever hayfever (Pinteraction = 0.07), allergic eye symptoms <12 mo (Pinteraction = 0.09); their risk allele was G in Russians and A in Finns. An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between ‘Western’ and ‘Eastern’ environments. Objectives: We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Methods: Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C‐159T and CC16 A38G. Results: For both CD14 C‐159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C‐159T, an interactive effect on ever itchy rash (Pinteraction = 0.004), itchy rash <12 mo (Pinteraction = 0.001) and dry cough at night in the past 12 months (<12 months) (Pinteraction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (Pinteraction = 0.006), rhinitis <12 mo (Pinteraction = 0.004), and marginally significant for ever hayfever (Pinteraction = 0.07), allergic eye symptoms <12 mo (Pinteraction = 0.09); their risk allele was G in Russians and A in Finns. Conclusion: An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyze genetic and allergic disease interactions between 'Western' and 'Eastern' environments. We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash ( P interaction = 0.004), itchy rash <12 mo ( P interaction = 0.001) and dry cough at night in the past 12 months (<12 months) ( P interaction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis ( P interaction = 0.006), rhinitis <12 mo ( P interaction = 0.004), and marginally significant for ever hayfever ( P interaction = 0.07), allergic eye symptoms <12 mo ( P interaction = 0.09); their risk allele was G in Russians and A in Finns. An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. [PUBLICATION ABSTRACT] |
Author | Zhang, G Pekkarinen, P Haahtela, T Laatikainen, T Vartiainen, E Le Souëf, P.N von Hertzen, L Goldblatt, J Hayden, C.M Khoo, S.-K Mäkelä, M |
Author_xml | – sequence: 1 fullname: Zhang, G – sequence: 2 fullname: Khoo, S.-K – sequence: 3 fullname: Laatikainen, T – sequence: 4 fullname: Pekkarinen, P – sequence: 5 fullname: Vartiainen, E – sequence: 6 fullname: von Hertzen, L – sequence: 7 fullname: Hayden, C.M – sequence: 8 fullname: Goldblatt, J – sequence: 9 fullname: Mäkelä, M – sequence: 10 fullname: Haahtela, T – sequence: 11 fullname: Le Souëf, P.N |
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Keywords | Lung disease Allergy Immunopathology genetic risk factors Genetic variability Dermatology Respiratory disease Genotype Exposure Epidemiology Asthma Immunology Genotype environment interaction Risk factor Bronchus disease Environment Genetics Obstructive pulmonary disease Single nucleotide polymorphism respiratory diseases environmental exposures |
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Snippet | Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the... Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic... Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic... Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic... BACKGROUNDFinnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group,... |
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SubjectTerms | Adult Alleles Allergies asthma Biological and medical sciences Chronic obstructive pulmonary disease, asthma Dermatology Environment environmental exposures Female Finland - ethnology Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Frequency - genetics genetic risk factors Genetics Genetics, Population Genotype Humans Hypersensitivity - epidemiology Hypersensitivity - genetics Hypersensitivity - immunology Lipopolysaccharide Receptors - genetics Lipopolysaccharide Receptors - immunology Logistic Models Medical sciences Minority & ethnic groups Pneumology Polymorphism, Single Nucleotide - genetics Polymorphism, Single Nucleotide - immunology Prevalence respiratory diseases respiratory tract diseases Risk factors Russia - epidemiology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Uteroglobin - genetics Uteroglobin - immunology Women |
Title | Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy |
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