The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells

• Published in: Advanced science Vol. 10; no. 35; pp. e2303799 - n/a
• Main Authors: Liu, Fang, Liu, Zhun, Cheng, Weisheng, Zhao, Qingquan, Zhang, Xinyu, Zhang, He, Yu, Miao, Xu, He, Gao, Yichen, Jiang, Qianrui, Shi, Guojun, Wang, Likun, Gu, Shanshan, Wang, Jia, Cao, Nan, Chen, Zhongyan
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.12.2023; John Wiley and Sons Inc; Wiley
• Subjects: Experiments; Heart; Homeostasis; human pluripotent stem cells; Kinases; mesendoderm specification; PERK; Protein folding; Protein synthesis; proteostasis; Stem cells; unfolded protein response; mesendoderm specification; unfolded protein response; PERK; human pluripotent stem cells; proteostasis

Cardiac development involves large‐scale rearrangements of the proteome. How the developing cardiac cells maintain the integrity of the proteome during the rapid lineage transition remains unclear. Here it is shown that proteotoxic stress visualized by the misfolded and/or aggregated proteins appear...