MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 36; no. 1; pp. 122 - 133
• Main Authors: Schlosser, Anders, Pilecki, Bartosz, Hemstra, Line E, Kejling, Karin, Kristmannsdottir, Gudlaug B, Wulf-Johansson, Helle, Moeller, Jesper B, Füchtbauer, Ernst-Martin, Nielsen, Ole, Kirketerp-Møller, Katrine, Dubey, Lalit K, Hansen, Pernille B.L, Stubbe, Jane, Wrede, Christoph, Hegermann, Jan, Ochs, Matthias, Rathkolb, Birgit, Schrewe, Anja, Bekeredjian, Raffi, Wolf, Eckhard, Gailus-Durner, Valérie, Fuchs, Helmut, Hrabě de Angelis, Martin, Lindholt, Jes S, Holmskov, Uffe, Sorensen, Grith L
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.01.2016
• Subjects: Animals; Apoptosis; Carotid Arteries - metabolism; Carotid Arteries - pathology; Carotid Artery Diseases - genetics; Carotid Artery Diseases - metabolism; Carotid Artery Diseases - pathology; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Movement - drug effects; Cell Proliferation - drug effects; Cells, Cultured; Chemotaxis, Leukocyte; Disease Models, Animal; Extracellular Matrix Proteins - deficiency; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Focal Adhesion Kinase 1 - antagonists & inhibitors; Focal Adhesion Kinase 1 - metabolism; Genotype; Glycoproteins - deficiency; Glycoproteins - genetics; Glycoproteins - metabolism; Humans; Hyperplasia; Integrin alphaVbeta3 - metabolism; Ligands; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Monocytes - metabolism; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Neointima; Phenotype; Phosphorylation; Protein Kinase Inhibitors - pharmacology; Signal Transduction; Time Factors; Vascular Remodeling; mouse; extracellular matrix proteins; integrin alphaVbeta3; muscle; hyperplasia; carotid stenosis; vascular; MFAP4 protein; smooth

OBJECTIVE—Arterial injury stimulates remodeling responses that, when excessive, lead to stenosis. These responses are influenced by integrin signaling in vascular smooth muscle cells (VSMCs). Microfibrillar-associated protein 4 (MFAP4) is an integrin ligand localized to extracellular matrix fibers i...