Oncogenic KRAS, Mucin 4, and Activin A‐Mediated Fibroblast Activation Cooperate for PanIN Initiation

• Published in: Advanced science Vol. 10; no. 36; pp. e2301240 - n/a
• Main Authors: Hu, Chun‐Mei, Huang, Chien‐Chang, Hsu, Min‐Fen, Chien, Hung‐Jen, Wu, Pei‐Jung, Chen, Yi‐Ing, Jeng, Yung‐Ming, Tang, Shiue‐Cheng, Chung, Mei‐Hsin, Shen, Chia‐Ning, Chang, Ming‐Chu, Chang, Yu‐Ting, Tien, Yu‐Wen, Lee, Wen‐Hwa
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.12.2023; John Wiley and Sons Inc; Wiley
• Subjects: activin A; Animals; Carcinoma in Situ - genetics; Carcinoma in Situ - pathology; Carcinoma, Pancreatic Ductal - genetics; Fibroblasts; Genes; Genomes; Humans; Kras; Metastasis; Mice; Mice, Transgenic; Muc4; Mucin-4; Mutation; Pancreatic cancer; Pancreatic Neoplasms - genetics; PanIN; Proto-Oncogene Proteins p21(ras) - genetics; Transgenic animals; αSMA+ fibroblast; αSMA+ fibroblast; Kras; Muc4; PanIN; activin A

Over 90% of patients with pancreatic ductal adenocarcinoma (PDAC) have oncogenic KRAS mutations. Nevertheless, mutated KRAS alone is insufficient to initiate pancreatic intraepithelial neoplasia (PanIN), the precursor of PDAC. The identities of the other factors/events required to drive PanIN format...