In vivo delivery of heat shock protein 70 accelerates wound healing by up-regulating macrophage-mediated phagocytosis

• Published in: Wound repair and regeneration Vol. 14; no. 2; pp. 129 - 137
• Main Authors: Kovalchin, PhD, Joseph T., Wang, MD, PhD, Ruibo, Wagh, MD, Mihir S., Azoulay, BS, Jason, Sanders, MD, Melinda, Chandawarkar, Rajiv Y.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.03.2006
• Subjects: Animals; Cells, Cultured; Chemokine CCL2 - metabolism; Female; HSP70 Heat-Shock Proteins - pharmacology; HSP90 Heat-Shock Proteins - pharmacology; Interleukin-6 - metabolism; Macrophages - drug effects; Membrane Glycoproteins - pharmacology; Mice; Mice, Inbred BALB C; Phagocytosis - drug effects; Tumor Necrosis Factor-alpha - metabolism; Up-Regulation; Wound Healing - drug effects

ABSTRACT Injury causes tissue breakdown, which releases large quantities of intracellular contents into the extracellular space. Some of these materials are well‐established activators of the immune system and include heat shock proteins (HSPs), uric acid, nucleotides, High Mobility Group Box‐1 prot...