Long-term evaluation of the degradation behavior of three apatite-forming calcium phosphate cements

• Published in: Journal of biomedical materials research. Part A Vol. 104; no. 5; pp. 1072 - 1081
• Main Authors: An, Jie, Liao, Hongbing, Kucko, Nathan W., Herber, Ralf-Peter, Wolke, Joop G. C., van den Beucken, Jeroen J. J. P., Jansen, John A., Leeuwenburgh, Sander C. G.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.05.2016; Wiley Subscription Services, Inc
• Subjects: Absorbable Implants; Animals; Apatites - chemistry; Apatites - metabolism; Biocompatibility; Biomedical materials; bone; Bone Cements - chemistry; Bone Cements - metabolism; Bone Substitutes - chemistry; Bone Substitutes - metabolism; Bones; Calcium phosphate; calcium phosphate cement; Calcium phosphates; Calcium Phosphates - chemistry; Calcium Phosphates - metabolism; Carboxymethylcellulose Sodium - chemistry; Carboxymethylcellulose Sodium - metabolism; Cements; CMC; Cohesion; Degradation; Female; Femur - injuries; Femur - pathology; Femur - physiology; Femur - ultrastructure; in vivo response; Lactic Acid - chemistry; Lactic Acid - metabolism; Materials Testing; Microparticles; Osteogenesis; PLGA; Polyglycolic Acid - chemistry; Polyglycolic Acid - metabolism; Porosity; Rabbits; Surgical implants; CMC; bone; PLGA; in vivo response; calcium phosphate cement

Calcium phosphate cements (CPCs) are injectable bone substitutes with a long clinical history because of their biocompatibility and osteoconductivity. Nevertheless, their cohesion upon injection into perfused bone defects as well as their long‐term degradation behavior remain major clinical challeng...