A longitudinal examination of the psychoeducational, neurocognitive, and psychiatric functioning in children with 22q11.2 deletion syndrome

• Published in: Research in developmental disabilities Vol. 34; no. 5; pp. 1758 - 1769
• Main Authors: Hooper, Stephen R., Curtiss, Kathleen, Schoch, Kelly, Keshavan, Matcheri S., Allen, Andrew, Shashi, Vandana
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.05.2013; Elsevier
• Subjects: 22q11.2 deletion syndrome; Academic Achievement; Adolescent; Adolescent Development - physiology; Adolescents; Adult and adolescent clinical studies; Biological and medical sciences; Child; Child Development - physiology; Children; Cognition - physiology; Depressive Disorder, Major - genetics; Depressive Disorder, Major - rehabilitation; DiGeorge syndrome; DiGeorge Syndrome - genetics; DiGeorge Syndrome - psychology; DiGeorge Syndrome - rehabilitation; Education of Intellectually Disabled; Female; Follow-Up Studies; Genetic Disorders; Humans; Intelligence - genetics; Intelligence Quotient; Late Adolescents; Linear Models; Longitudinal Studies; Male; Medical sciences; Mental Disorders; Mental Disorders - genetics; Mental Disorders - rehabilitation; Neurocognitive functioning in 22q11DS; Neuropsychological Tests; Obsessive-Compulsive Disorder - genetics; Obsessive-Compulsive Disorder - rehabilitation; Older children; Psychiatric functioning in 22q11DS; Psychoeducational functioning in 22q11DS; Psychology. Psychoanalysis. Psychiatry; Psychopathology; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - genetics; Schizophrenia - rehabilitation; Social Behavior; Symptoms; Symptoms (Individual Disorders); Velocardiofacial syndrome; 22q11.2 deletion syndrome; Neurocognitive functioning in 22q11DS; Schizophrenia genetics; DiGeorge syndrome; Psychoeducational functioning in 22q11DS; Velocardiofacial syndrome; Psychiatric functioning in 22q11DS; Human; Immunopathology; Central nervous system; Schizophrenia; Cognition; Developmental disorder; Di George's syndrome; Psychoeducation; Encephalon; Psychosis; Treatment; Follow up study; Genetics; Child

► Children with 22q11DS and controls underwent two neurocognitive and psychiatric evaluations 3.5 years apart. ► Significant cognitive deficits and higher incidence of psychiatric manifestations seen in 22q11DS children relative to controls at both T1 and T2. ► Slowed growth in attention, increased...