A longitudinal examination of the psychoeducational, neurocognitive, and psychiatric functioning in children with 22q11.2 deletion syndrome
► Children with 22q11DS and controls underwent two neurocognitive and psychiatric evaluations 3.5 years apart. ► Significant cognitive deficits and higher incidence of psychiatric manifestations seen in 22q11DS children relative to controls at both T1 and T2. ► Slowed growth in attention, increased...
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| Published in | Research in developmental disabilities Vol. 34; no. 5; pp. 1758 - 1769 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier Ltd
01.05.2013
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | ► Children with 22q11DS and controls underwent two neurocognitive and psychiatric evaluations 3.5 years apart. ► Significant cognitive deficits and higher incidence of psychiatric manifestations seen in 22q11DS children relative to controls at both T1 and T2. ► Slowed growth in attention, increased psychiatric symptoms and prodromal signs, and decreased GAF over time noted in 22q11DS children. ► T1 predictors of psychopathology at T2 included full-scale IQ and social-behavioral problems.
The present study sought to examine the longitudinal psychoeducational, neurocognitive, and psychiatric outcomes of children and adolescents with chromosome 22q11.2 deletion syndrome (22q11DS), a population with a high incidence of major psychiatric illnesses appearing in late adolescence/early adulthood. Little is known of the developmental changes that occur in the early teen years, prior to the age of highest psychosis risk. Data were collected from 71 participants (42 subjects with 22q11DS and 29 control subjects) at Time 1 (T1) and Time 2 (T2), approximately 3.5 years later. The 22q11DS group was significantly lower functioning than controls on IQ, neurocognition, and academic achievement at both T1 and T2. Children with 22q11DS also showed significantly greater social-behavioral difficulties and psychiatric symptoms, and were more likely to meet criteria for psychiatric disorders at both time points. In evaluating change over time from T1 to T2, the 22q11DS group did not show significant changes in psychoeducational or psychiatric outcomes relative to the controls, however, lack of expected age-related gains in attention regulation were noted. Within the 22q11DS group, an increase in the Attenuated Prodrome for Schizophrenia (number of psychiatric symptoms) was noted from T1 to T2 and four children with 22q11DS met criteria for Psychosis for the first time. Predictors at T1 that uncovered psychopathology symptoms at T2 included full-scale IQ, externalizing symptoms, and problem social behaviors. Overall, younger adolescent and preadolescent children with 22q11DS in this study exhibited slowed growth in attention regulation, with an increase in subclinical symptoms of schizophrenia, suggestive of increasing impairments in domains that are relevant to the high risk of Schizophrenia. Early predictors of later psychopathology included both cognitive and behavioral abnormalities. These findings begin to elucidate the trajectory of changes in psychopathology in children with 22q11DS in the years leading up to the onset of major psychiatric illnesses. |
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| AbstractList | The present study sought to examine the longitudinal psychoeducational, neurocognitive, and psychiatric outcomes of children and adolescents with chromosome 22q11.2 deletion syndrome (22q11DS), a population with a high incidence of major psychiatric illnesses appearing in late adolescence/early adulthood. Little is known of the developmental changes that occur in the early teen years, prior to the age of highest psychosis risk. Data were collected from 71 participants (42 subjects with 22q11DS and 29 control subjects) at Time 1 (T1) and Time 2 (T2), approximately 3.5 years later. The 22q11DS group was significantly lower functioning than controls on IQ, neurocognition, and academic achievement at both T1 and T2. Children with 22q11DS also showed significantly greater social-behavioral difficulties and psychiatric symptoms, and were more likely to meet criteria for psychiatric disorders at both time points. In evaluating change over time from T1 to T2, the 22q11DS group did not show significant changes in psychoeducational or psychiatric outcomes relative to the controls, however, lack of expected age-related gains in attention regulation were noted. Within the 22q11DS group, an increase in the Attenuated Prodrome for Schizophrenia (number of psychiatric symptoms) was noted from T1 to T2 and four children with 22q11DS met criteria for Psychosis for the first time. Predictors at T1 that uncovered psychopathology symptoms at T2 included full-scale IQ, externalizing symptoms, and problem social behaviors. Overall, younger adolescent and preadolescent children with 22q11DS in this study exhibited slowed growth in attention regulation, with an increase in subclinical symptoms of schizophrenia, suggestive of increasing impairments in domains that are relevant to the high risk of Schizophrenia. Early predictors of later psychopathology included both cognitive and behavioral abnormalities. These findings begin to elucidate the trajectory of changes in psychopathology in children with 22q11DS in the years leading up to the onset of major psychiatric illnesses. (Contains 1 figure and 3 tables.) The present study sought to examine the longitudinal psychoeducational, neurocognitive, and psychiatric outcomes of children and adolescents with chromosome 22q11.2 deletion syndrome (22q11DS), a population with a high incidence of major psychiatric illnesses appearing in late adolescence/early adulthood. Little is known of the developmental changes that occur in the early teen years, prior to the age of highest psychosis risk. Data were collected from 71 participants (42 subjects with 22q11DS and 29 control subjects) at Time 1 (T1) and Time 2 (T2), approximately 3.5 years later. The 22q11DS group was significantly lower functioning than controls on IQ, neurocognition, and academic achievement at both T1 and T2. Children with 22q11DS also showed significantly greater social-behavioral difficulties and psychiatric symptoms, and were more likely to meet criteria for psychiatric disorders at both time points. In evaluating change over time from T1 to T2, the 22q11DS group did not show significant changes in psychoeducational or psychiatric outcomes relative to the controls, however, lack of expected age-related gains in attention regulation were noted. Within the 22q11DS group, an increase in the Attenuated Prodrome for Schizophrenia (number of psychiatric symptoms) was noted from T1 to T2 and four children with 22q11DS met criteria for Psychosis for the first time. Predictors at T1 that uncovered psychopathology symptoms at T2 included full-scale IQ, externalizing symptoms, and problem social behaviors. Overall, younger adolescent and preadolescent children with 22q11DS in this study exhibited slowed growth in attention regulation, with an increase in subclinical symptoms of schizophrenia, suggestive of increasing impairments in domains that are relevant to the high risk of Schizophrenia. Early predictors of later psychopathology included both cognitive and behavioral abnormalities. These findings begin to elucidate the trajectory of changes in psychopathology in children with 22q11DS in the years leading up to the onset of major psychiatric illnesses. [Copyright Elsevier B.V.] The present study sought to examine the longitudinal psychoeducational, neurocognitive, and psychiatric outcomes of children and adolescents with chromosome 22q11.2 deletion syndrome (22q11DS), a population with a high incidence of major psychiatric illnesses appearing in late adolescence/early adulthood. Little is known of the developmental changes that occur in the early teen years, prior to the age of highest psychosis risk. Data were collected from 71 participants (42 subjects with 22q11DS and 29 control subjects) at Time 1 (T1) and Time 2 (T2), approximately 3.5 years later. The 22q11DS group was significantly lower functioning than controls on IQ, neurocognition, and academic achievement at both T1 and T2. Children with 22q11DS also showed significantly greater social-behavioral difficulties and psychiatric symptoms, and were more likely to meet criteria for psychiatric disorders at both time points. In evaluating change over time from T1 to T2, the 22q11DS group did not show significant changes in psychoeducational or psychiatric outcomes relative to the controls, however, lack of expected age-related gains in attention regulation were noted. Within the 22q11DS group, an increase in the Attenuated Prodrome for Schizophrenia (number of psychiatric symptoms) was noted from T1 to T2 and four children with 22q11DS met criteria for Psychosis for the first time. Predictors at T1 that uncovered psychopathology symptoms at T2 included full-scale IQ, externalizing symptoms, and problem social behaviors. Overall, younger adolescent and preadolescent children with 22q11DS in this study exhibited slowed growth in attention regulation, with an increase in subclinical symptoms of schizophrenia, suggestive of increasing impairments in domains that are relevant to the high risk of Schizophrenia. Early predictors of later psychopathology included both cognitive and behavioral abnormalities. These findings begin to elucidate the trajectory of changes in psychopathology in children with 22q11DS in the years leading up to the onset of major psychiatric illnesses. The present study sought to examine the longitudinal psychoeducational, neurocognitive, and psychiatric outcomes of children and adolescents with chromosome 22q11.2 deletion syndrome (22q11DS), a population with a high incidence of major psychiatric illnesses appearing in late adolescence/early adulthood. Little is known of the developmental changes that occur in the early teen years, prior to the age of highest psychosis risk. Data were collected from 71 participants (42 subjects with 22q11DS and 29 control subjects) at Time 1 (T1) and Time 2 (T2), approximately 3.5 years later. The 22q11DS group was significantly lower functioning than controls on IQ, neurocognition, and academic achievement at both T1 and T2. Children with 22q11DS also showed significantly greater social-behavioral difficulties and psychiatric symptoms, and were more likely to meet criteria for psychiatric disorders at both time points. In evaluating change over time from T1 to T2, the 22q11DS group did not show significant changes in psychoeducational or psychiatric outcomes relative to the controls, however, lack of expected age-related gains in attention regulation were noted. Within the 22q11DS group, an increase in the Attenuated Prodrome for Schizophrenia (number of psychiatric symptoms) was noted from T1 to T2 and four children with 22q11DS met criteria for Psychosis for the first time. Predictors at T1 that uncovered psychopathology symptoms at T2 included full-scale IQ, externalizing symptoms, and problem social behaviors. Overall, younger adolescent and preadolescent children with 22q11DS in this study exhibited slowed growth in attention regulation, with an increase in subclinical symptoms of schizophrenia, suggestive of increasing impairments in domains that are relevant to the high risk of Schizophrenia. Early predictors of later psychopathology included both cognitive and behavioral abnormalities. These findings begin to elucidate the trajectory of changes in psychopathology in children with 22q11DS in the years leading up to the onset of major psychiatric illnesses.The present study sought to examine the longitudinal psychoeducational, neurocognitive, and psychiatric outcomes of children and adolescents with chromosome 22q11.2 deletion syndrome (22q11DS), a population with a high incidence of major psychiatric illnesses appearing in late adolescence/early adulthood. Little is known of the developmental changes that occur in the early teen years, prior to the age of highest psychosis risk. Data were collected from 71 participants (42 subjects with 22q11DS and 29 control subjects) at Time 1 (T1) and Time 2 (T2), approximately 3.5 years later. The 22q11DS group was significantly lower functioning than controls on IQ, neurocognition, and academic achievement at both T1 and T2. Children with 22q11DS also showed significantly greater social-behavioral difficulties and psychiatric symptoms, and were more likely to meet criteria for psychiatric disorders at both time points. In evaluating change over time from T1 to T2, the 22q11DS group did not show significant changes in psychoeducational or psychiatric outcomes relative to the controls, however, lack of expected age-related gains in attention regulation were noted. Within the 22q11DS group, an increase in the Attenuated Prodrome for Schizophrenia (number of psychiatric symptoms) was noted from T1 to T2 and four children with 22q11DS met criteria for Psychosis for the first time. Predictors at T1 that uncovered psychopathology symptoms at T2 included full-scale IQ, externalizing symptoms, and problem social behaviors. Overall, younger adolescent and preadolescent children with 22q11DS in this study exhibited slowed growth in attention regulation, with an increase in subclinical symptoms of schizophrenia, suggestive of increasing impairments in domains that are relevant to the high risk of Schizophrenia. Early predictors of later psychopathology included both cognitive and behavioral abnormalities. These findings begin to elucidate the trajectory of changes in psychopathology in children with 22q11DS in the years leading up to the onset of major psychiatric illnesses. ► Children with 22q11DS and controls underwent two neurocognitive and psychiatric evaluations 3.5 years apart. ► Significant cognitive deficits and higher incidence of psychiatric manifestations seen in 22q11DS children relative to controls at both T1 and T2. ► Slowed growth in attention, increased psychiatric symptoms and prodromal signs, and decreased GAF over time noted in 22q11DS children. ► T1 predictors of psychopathology at T2 included full-scale IQ and social-behavioral problems. The present study sought to examine the longitudinal psychoeducational, neurocognitive, and psychiatric outcomes of children and adolescents with chromosome 22q11.2 deletion syndrome (22q11DS), a population with a high incidence of major psychiatric illnesses appearing in late adolescence/early adulthood. Little is known of the developmental changes that occur in the early teen years, prior to the age of highest psychosis risk. Data were collected from 71 participants (42 subjects with 22q11DS and 29 control subjects) at Time 1 (T1) and Time 2 (T2), approximately 3.5 years later. The 22q11DS group was significantly lower functioning than controls on IQ, neurocognition, and academic achievement at both T1 and T2. Children with 22q11DS also showed significantly greater social-behavioral difficulties and psychiatric symptoms, and were more likely to meet criteria for psychiatric disorders at both time points. In evaluating change over time from T1 to T2, the 22q11DS group did not show significant changes in psychoeducational or psychiatric outcomes relative to the controls, however, lack of expected age-related gains in attention regulation were noted. Within the 22q11DS group, an increase in the Attenuated Prodrome for Schizophrenia (number of psychiatric symptoms) was noted from T1 to T2 and four children with 22q11DS met criteria for Psychosis for the first time. Predictors at T1 that uncovered psychopathology symptoms at T2 included full-scale IQ, externalizing symptoms, and problem social behaviors. Overall, younger adolescent and preadolescent children with 22q11DS in this study exhibited slowed growth in attention regulation, with an increase in subclinical symptoms of schizophrenia, suggestive of increasing impairments in domains that are relevant to the high risk of Schizophrenia. Early predictors of later psychopathology included both cognitive and behavioral abnormalities. These findings begin to elucidate the trajectory of changes in psychopathology in children with 22q11DS in the years leading up to the onset of major psychiatric illnesses. |
| Author | Hooper, Stephen R. Keshavan, Matcheri S. Schoch, Kelly Shashi, Vandana Allen, Andrew Curtiss, Kathleen |
| AuthorAffiliation | a Department of Psychiatry and The Carolina Institute for Developmental Disabilities, University of North Carolina School of Medicine, CB# 7255, Chapel Hill, NC, USA, 27599-7255 b Department of Psychiatry, Duke University Medical School, GSRB1 Box 103857, 595 LaSalle St., Durham, NC, USA, 27710 d Department of Biostatistics, Duke University School of Medicine, 7057 North Pavilion, Durham, NC, USA 27710 c Department of Psychiatry, Harvard Medical School, Commonwealth Research Center, 75 Fenwood Rd, 5 th Floor, Boston, MA, USA, 02115 |
| AuthorAffiliation_xml | – name: c Department of Psychiatry, Harvard Medical School, Commonwealth Research Center, 75 Fenwood Rd, 5 th Floor, Boston, MA, USA, 02115 – name: d Department of Biostatistics, Duke University School of Medicine, 7057 North Pavilion, Durham, NC, USA 27710 – name: b Department of Psychiatry, Duke University Medical School, GSRB1 Box 103857, 595 LaSalle St., Durham, NC, USA, 27710 – name: a Department of Psychiatry and The Carolina Institute for Developmental Disabilities, University of North Carolina School of Medicine, CB# 7255, Chapel Hill, NC, USA, 27599-7255 |
| Author_xml | – sequence: 1 givenname: Stephen R. surname: Hooper fullname: Hooper, Stephen R. organization: Department of Psychiatry and The Carolina Institute for Developmental Disabilities, University of North Carolina School of Medicine, CB# 7255, Chapel Hill, NC 27599-7255, USA – sequence: 2 givenname: Kathleen surname: Curtiss fullname: Curtiss, Kathleen email: kathleen.curtiss@duke.edu organization: Department of Pediatrics, Duke University Medical School, GSRB1 Box 103857, 595 LaSalle St., Durham, NC 27710, USA – sequence: 3 givenname: Kelly surname: Schoch fullname: Schoch, Kelly organization: Department of Pediatrics, Duke University Medical School, GSRB1 Box 103857, 595 LaSalle St., Durham, NC 27710, USA – sequence: 4 givenname: Matcheri S. surname: Keshavan fullname: Keshavan, Matcheri S. organization: Department of Psychiatry, Harvard Medical School, Commonwealth Research Center, 75 Fenwood Rd, 5th Floor, Boston, MA 02115, USA – sequence: 5 givenname: Andrew surname: Allen fullname: Allen, Andrew organization: Department of Biostatistics, Duke University School of Medicine, 7057 North Pavilion, Durham, NC 27710, USA – sequence: 6 givenname: Vandana surname: Shashi fullname: Shashi, Vandana email: vandana.shashi@duke.edu organization: Department of Pediatrics, Duke University Medical School, GSRB1 Box 103857, 595 LaSalle St., Durham, NC 27710, USA |
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| Keywords | 22q11.2 deletion syndrome Neurocognitive functioning in 22q11DS Schizophrenia genetics DiGeorge syndrome Psychoeducational functioning in 22q11DS Velocardiofacial syndrome Psychiatric functioning in 22q11DS Human Immunopathology Central nervous system Schizophrenia Cognition Developmental disorder Di George's syndrome Psychoeducation Encephalon Psychosis Treatment Follow up study Genetics Child |
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| Snippet | ► Children with 22q11DS and controls underwent two neurocognitive and psychiatric evaluations 3.5 years apart. ► Significant cognitive deficits and higher... The present study sought to examine the longitudinal psychoeducational, neurocognitive, and psychiatric outcomes of children and adolescents with chromosome... |
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| SubjectTerms | 22q11.2 deletion syndrome Academic Achievement Adolescent Adolescent Development - physiology Adolescents Adult and adolescent clinical studies Biological and medical sciences Child Child Development - physiology Children Cognition - physiology Depressive Disorder, Major - genetics Depressive Disorder, Major - rehabilitation DiGeorge syndrome DiGeorge Syndrome - genetics DiGeorge Syndrome - psychology DiGeorge Syndrome - rehabilitation Education of Intellectually Disabled Female Follow-Up Studies Genetic Disorders Humans Intelligence - genetics Intelligence Quotient Late Adolescents Linear Models Longitudinal Studies Male Medical sciences Mental Disorders Mental Disorders - genetics Mental Disorders - rehabilitation Neurocognitive functioning in 22q11DS Neuropsychological Tests Obsessive-Compulsive Disorder - genetics Obsessive-Compulsive Disorder - rehabilitation Older children Psychiatric functioning in 22q11DS Psychoeducational functioning in 22q11DS Psychology. Psychoanalysis. Psychiatry Psychopathology Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - genetics Schizophrenia - rehabilitation Social Behavior Symptoms Symptoms (Individual Disorders) Velocardiofacial syndrome |
| Title | A longitudinal examination of the psychoeducational, neurocognitive, and psychiatric functioning in children with 22q11.2 deletion syndrome |
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