The clinical and immunological features of pediatric COVID-19 patients in China
In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve...
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| Published in | Genes & diseases Vol. 7; no. 4; pp. 535 - 541 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
China
Elsevier B.V
01.12.2020
Chongqing Medical University KeAi Communications Co., Ltd |
| Subjects | |
| Online Access | Get full text |
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| Abstract | In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. The immunological features of children patients was investigated and compared with twenty adult patients. The median age was 14.5-years (range from 0.64 to 17), and six of the patients were male. The average incubation period was 8 days. Clinically, cough (9/12, 75%) and fever (7/12, 58.3%) were the most common symptoms. Four patients (33.3%) had diarrhea during the disease. As to the immune profile, children had higher amount of total T cell, CD8+ T cell and B cell but lower CRP levels than adults (P < 0.05). Ground-glass opacity (GGO) and local patchy shadowing were the typical radiological findings on chest CT scan. All patients received antiviral and symptomatic treatment and the symptom relieved in 3–4 days after admitted to hospital. The paediatric patients showed mild symptom but with longer incubation period. Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level, which might ascribed to the mild clinical symptom. We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom. |
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| AbstractList | In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. The immunological features of children patients was investigated and compared with twenty adult patients. The median age was 14.5-years (range from 0.64 to 17), and six of the patients were male. The average incubation period was 8 days. Clinically, cough (9/12, 75%) and fever (7/12, 58.3%) were the most common symptoms. Four patients (33.3%) had diarrhea during the disease. As to the immune profile, children had higher amount of total T cell, CD8+ T cell and B cell but lower CRP levels than adults (P < 0.05). Ground-glass opacity (GGO) and local patchy shadowing were the typical radiological findings on chest CT scan. All patients received antiviral and symptomatic treatment and the symptom relieved in 3–4 days after admitted to hospital. The paediatric patients showed mild symptom but with longer incubation period. Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level, which might ascribed to the mild clinical symptom. We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom. In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. The immunological features of children patients was investigated and compared with twenty adult patients. The median age was 14.5-years (range from 0.64 to 17), and six of the patients were male. The average incubation period was 8 days. Clinically, cough (9/12, 75%) and fever (7/12, 58.3%) were the most common symptoms. Four patients (33.3%) had diarrhea during the disease. As to the immune profile, children had higher amount of total T cell, CD8+ T cell and B cell but lower CRP levels than adults (P < 0.05). Ground-glass opacity (GGO) and local patchy shadowing were the typical radiological findings on chest CT scan. All patients received antiviral and symptomatic treatment and the symptom relieved in 3-4 days after admitted to hospital. The paediatric patients showed mild symptom but with longer incubation period. Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level, which might ascribed to the mild clinical symptom. We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom.In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. The immunological features of children patients was investigated and compared with twenty adult patients. The median age was 14.5-years (range from 0.64 to 17), and six of the patients were male. The average incubation period was 8 days. Clinically, cough (9/12, 75%) and fever (7/12, 58.3%) were the most common symptoms. Four patients (33.3%) had diarrhea during the disease. As to the immune profile, children had higher amount of total T cell, CD8+ T cell and B cell but lower CRP levels than adults (P < 0.05). Ground-glass opacity (GGO) and local patchy shadowing were the typical radiological findings on chest CT scan. All patients received antiviral and symptomatic treatment and the symptom relieved in 3-4 days after admitted to hospital. The paediatric patients showed mild symptom but with longer incubation period. Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level, which might ascribed to the mild clinical symptom. We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom. In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. The immunological features of children patients was investigated and compared with twenty adult patients. The median age was 14.5-years (range from 0.64 to 17), and six of the patients were male. The average incubation period was 8 days. Clinically, cough (9/12, 75%) and fever (7/12, 58.3%) were the most common symptoms. Four patients (33.3%) had diarrhea during the disease. As to the immune profile, children had higher amount of total T cell, CD8+ T cell and B cell but lower CRP levels than adults ( < 0.05). Ground-glass opacity (GGO) and local patchy shadowing were the typical radiological findings on chest CT scan. All patients received antiviral and symptomatic treatment and the symptom relieved in 3-4 days after admitted to hospital. The paediatric patients showed mild symptom but with longer incubation period. Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level, which might ascribed to the mild clinical symptom. We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom. In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. The immunological features of children patients was investigated and compared with twenty adult patients. The median age was 14.5-years (range from 0.64 to 17), and six of the patients were male. The average incubation period was 8 days. Clinically, cough (9/12, 75%) and fever (7/12, 58.3%) were the most common symptoms. Four patients (33.3%) had diarrhea during the disease. As to the immune profile, children had higher amount of total T cell, CD8+ T cell and B cell but lower CRP levels than adults ( P < 0.05). Ground-glass opacity (GGO) and local patchy shadowing were the typical radiological findings on chest CT scan. All patients received antiviral and symptomatic treatment and the symptom relieved in 3–4 days after admitted to hospital. The paediatric patients showed mild symptom but with longer incubation period. Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level, which might ascribed to the mild clinical symptom. We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom. |
| Author | Chen, Yao-Kai Long, Quan-Xin Tang, Ni Hu, Jie-Li Pu-Liao Hu, Peng Xiang, Jiang-Lin Wu, Gui-Cheng Wang, De-Qiang Huang, Ai-Long Li, Zhi-Jie Tian, Wen-Guang Xu, Hong-Mei Cai, Xue-Fei Deng, Hai-Jun Zhang, Xian-Xiang Zhou, Fa-Chun Hu, Yuan Wang, Dao-Xin Liu, Bei-Zhong Zhang, Zhen-Zhen Chen, Juan |
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Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 5 givenname: Wen-Guang surname: Tian fullname: Tian, Wen-Guang organization: Department of Infectious Diseases, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, China – sequence: 6 givenname: Hai-Jun surname: Deng fullname: Deng, Hai-Jun organization: The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 7 givenname: Jie-Li surname: Hu fullname: Hu, Jie-Li organization: The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 8 givenname: Xian-Xiang surname: Zhang fullname: Zhang, Xian-Xiang organization: Department of Endocrinology, Chongqing Three Gorges Central Hospital, Chongqing, China – sequence: 9 surname: Pu-Liao fullname: Pu-Liao organization: Department of Clinical Laboratory, Chongqing People's Hospital, Chongqing, China – sequence: 10 givenname: Jiang-Lin surname: Xiang fullname: Xiang, Jiang-Lin organization: Department of Infectious Diseases, Chongqing Three Gorges Central Hospital, Chongqing, China – sequence: 11 givenname: Dao-Xin surname: Wang fullname: Wang, Dao-Xin organization: Department of Respiration, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 12 givenname: Peng surname: Hu fullname: Hu, Peng organization: The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 13 givenname: Fa-Chun surname: Zhou fullname: Zhou, Fa-Chun organization: Department of Emergency, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 14 givenname: Zhi-Jie surname: Li fullname: Li, Zhi-Jie organization: Department of Endocrinology, Chongqing Three Gorges Central Hospital, Chongqing, China – sequence: 15 givenname: Hong-Mei surname: Xu fullname: Xu, Hong-Mei organization: Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders, The Children's Hospital of Chongqing Medical University, Chongqing, China – sequence: 16 givenname: Xue-Fei surname: Cai fullname: Cai, Xue-Fei organization: The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 17 givenname: De-Qiang surname: Wang fullname: Wang, De-Qiang organization: The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 18 givenname: Yuan surname: Hu fullname: Hu, Yuan organization: The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 19 givenname: Ni surname: Tang fullname: Tang, Ni organization: The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 20 givenname: Bei-Zhong surname: Liu fullname: Liu, Bei-Zhong email: liubeizhong@cqmu.edu.cn organization: Department of Clinical Laboratory, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, China – sequence: 21 givenname: Gui-Cheng surname: Wu fullname: Wu, Gui-Cheng email: wuguic@hotmail.com organization: Department of Liver Disease, Chongqing Three Gorges Central Hospital, Chongqing, China – sequence: 22 givenname: Ai-Long surname: Huang fullname: Huang, Ai-Long email: ahuang@cqmu.edu.cn organization: The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32363222$$D View this record in MEDLINE/PubMed |
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