Efficacy of vaccination and previous infection against the Omicron BA.1 variant in Syrian hamsters

• Published in: Cell reports (Cambridge) Vol. 39; no. 3; p. 110688
• Main Authors: Halfmann, Peter J., Kuroda, Makoto, Maemura, Tadashi, Chiba, Shiho, Armbrust, Tammy, Wright, Ryan, Balaram, Ariane, Florek, Kelsey R., Bateman, Allen C., Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.04.2022; The Author(s)
• Subjects: Animals; Antibodies, Neutralizing; BA.1; COVID-19 - prevention & control; Cricetinae; Disease Models, Animal; immunity; Mesocricetus; mRNA Vaccines; Omicron; previous infection; SARS-CoV-2; Vaccination; Vaccines, Synthetic; previous infection; SARS-CoV-2; CP: Microbiology; Omicron; immunity; BA.1; vaccination

The emergence of the SARS-CoV-2 Omicron (B.1.1.529) variant with a surprising number of spike mutations raises concerns about reduced sensitivity of this virus to antibody neutralization and subsequent vaccine breakthrough infections. Here, we infect Moderna mRNA-vaccinated or previously infected ha...