Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals

• Published in: Cell reports (Cambridge) Vol. 36; no. 8; p. 109570
• Main Authors: Lozano-Ojalvo, Daniel, Camara, Carmen, Lopez-Granados, Eduardo, Nozal, Pilar, del Pino-Molina, Lucía, Bravo-Gallego, Luz Yadira, Paz-Artal, Estela, Pion, Marjorie, Correa-Rocha, Rafael, Ortiz, Alberto, Lopez-Hoyos, Marcos, Iribarren, Marta Erro, Portoles, Jose, Rojo-Portoles, Maria Pilar, Ojeda, Gloria, Cervera, Isabel, Gonzalez-Perez, Maria, Bodega-Mayor, Irene, Montes-Casado, Maria, Portoles, Pilar, Perez-Olmeda, Mayte, Oteo, Jesus, Sanchez-Tarjuelo, Rodrigo, Pothula, Venu, Schwarz, Megan, Brahmachary, Manisha, Tan, Anthony Tanoto, Le Bert, Nina, Berin, Cecilia, Bertoletti, Antonio, Guccione, Ernesto, Ochando, Jordi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.08.2021; The Authors; Elsevier
• Subjects: Antibodies, Viral - blood; BNT162b2 vaccine; CD40 Ligand - metabolism; COVID-19; COVID-19 - immunology; COVID-19 - pathology; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - chemistry; COVID-19 Vaccines - immunology; Humans; Immunity, Cellular; Immunity, Humoral; Immunoglobulin G - blood; Interferon-gamma - metabolism; Interleukin-2 - metabolism; mRNA Vaccines; Peptides - immunology; SARS-CoV-2; SARS-CoV-2 - isolation & purification; SARS-CoV-2 - metabolism; Spike Glycoprotein, Coronavirus - immunology; T-cell immunity; T-Lymphocytes - cytology; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Vaccination; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - immunology; COVID-19; T-cell immunity; BNT162b2 vaccine; SARS-CoV-2

The rapid development of mRNA-based vaccines against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to the design of accelerated vaccination schedules that have been extremely effective in naive individuals. While a two-dose immunization regimen with the BNT162b2 vaccine has be...