N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells

• Published in: Cell reports (Cambridge) Vol. 26; no. 3; pp. 652 - 669.e6
• Main Authors: Zhao, Meng, Tao, Fang, Venkatraman, Aparna, Li, Zhenrui, Smith, Sarah E., Unruh, Jay, Chen, Shiyuan, Ward, Christina, Qian, Pengxu, Perry, John M., Marshall, Heather, Wang, Jinxi, He, Xi C., Li, Linheng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.01.2019
• Subjects: Cadherins - metabolism; endosteum; Hematopoietic Stem Cells - physiology; Humans; MSC; N-cadherin; niche; reserve stem cell; Stem Cells - metabolism; stress response; Stromal Cells - metabolism; niche; stress response; MSC; endosteum; N-cadherin; reserve stem cell

Regulation of hematopoietic stem cells (HSCs) by bone marrow (BM) niches has been extensively studied; however, whether and how HSC subpopulations are distinctively regulated by BM niches remain unclear. Here, we functionally distinguished reserve HSCs (rHSCs) from primed HSCs (pHSCs) based on their...