Functional elements of the cis-regulatory lincRNA-p21

• Published in: Cell reports (Cambridge) Vol. 39; no. 3; p. 110687
• Main Authors: Winkler, Lauren, Jimenez, Maria, Zimmer, Joshua T., Williams, Adam, Simon, Matthew D., Dimitrova, Nadya
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.04.2022
• Subjects: cis-regulation; genetic models; lincRNA-p21; long noncoding RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; transcription; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; long noncoding RNA; cis-regulation; CP: Molecular biology; transcription; lincRNA-p21; genetic models

The p53-induced long noncoding RNA (lncRNA) lincRNA-p21 is proposed to act in cis to promote p53-dependent expression of the neighboring cell cycle gene, Cdkn1a/p21. The molecular mechanism through which the transcribed lincRNA-p21 regulatory locus activates p21 expression remains poorly understood....