Cytochrome P-450 Polymorphisms and Response to Clopidogrel - Mega, Jessica L; Close, Sandra L; Wiviott, Stephen D; Shen, Lei; Hockett, Richard D; Brandt, John T; Walker, Joseph R; Antman, Elliott M; Macias, William; Braunwald, Eugene; Sabatine, Marc S (The New England journal of medicine, 2009)
Keywords: Acute Coronary Syndrome - therapy; Adult; Angioplasty, Balloon, Coronary; Area Under Curve; Aryl Hydrocarbon Hydroxylases - genetics; Biological and medical sciences; Cardiovascular disease; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - genetics; Combined Modality Therapy; Cytochrome P-450 CYP2C19; Drug therapy; Female; General aspects; Genotype; Heart attacks; Heterozygote; Humans; Male; Medical sciences; Mutation; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - adverse effects; Platelet Aggregation Inhibitors - metabolism; Platelet Aggregation Inhibitors - pharmacology; Platelet Aggregation Inhibitors - therapeutic use; Polymorphism, Genetic; Randomized Controlled Trials as Topic; Stents; Studies; Thrombosis - epidemiology; Thrombosis - genetics; Ticlopidine - adverse effects; Ticlopidine - analogs & derivatives; Ticlopidine - metabolism; Ticlopidine - pharmacology; Ticlopidine - therapeutic use; Medicine; Genetic variability; Enzyme; Cytochrome P450; Antithrombotic agent; Clopidogrel; Genotype; Thienopyridine derivative; Antiplatelet agent; Polymorphism