Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome

• Published in: Cell reports (Cambridge) Vol. 30; no. 4; pp. 1152 - 1163.e4
• Main Authors: Chang, Pishan, Bush, Daniel, Schorge, Stephanie, Good, Mark, Canonica, Tara, Shing, Nathanael, Noy, Suzanna, Wiseman, Frances K., Burgess, Neil, Tybulewicz, Victor L.J., Walker, Matthew C., Fisher, Elizabeth M.C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.01.2020; Cell Press; Elsevier
• Subjects: Animals; Chromosomes, Human, Pair 21 - genetics; Cognitive Dysfunction - genetics; Cognitive Dysfunction - physiopathology; Disease Models, Animal; Down syndrome; Down Syndrome - genetics; Dyrk Kinases; Electroencephalography; executive function; functional connectivity; gamma; hippocampus; Hippocampus - metabolism; Hippocampus - physiopathology; Humans; Male; memory; Memory, Short-Term - physiology; Mice; Mice, Inbred C57BL; prefrontal cortex; Prefrontal Cortex - metabolism; Prefrontal Cortex - physiology; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - metabolism; Spatial Memory - physiology; theta; Theta Rhythm - genetics; Trisomy - genetics; Trisomy - physiopathology; Trisomy 21; Trisomy 21; memory; functional connectivity; hippocampus; prefrontal cortex; Down syndrome; theta; gamma; executive function

Altered neural dynamics in the medial prefrontal cortex (mPFC) and hippocampus may contribute to cognitive impairments in the complex chromosomal disorder Down syndrome (DS). Here, we demonstrate non-overlapping behavioral differences associated with distinct abnormalities in hippocampal and mPFC el...