Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice

• Published in: Blood Vol. 128; no. 14; pp. 1829 - 1833
• Main Authors: Saito, Yasuyuki, Ellegast, Jana M., Rafiei, Anahita, Song, Yuanbin, Kull, Daniel, Heikenwalder, Mathias, Rongvaux, Anthony, Halene, Stephanie, Flavell, Richard A., Manz, Markus G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.10.2016; American Society of Hematology
• Subjects: Animals; Animals, Newborn; Antigens, CD34 - metabolism; Brief Report; Cytokines - metabolism; Gene Knock-In Techniques; Hematopoiesis and Stem Cells; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells - cytology; Humans; Lymphoid Tissue - metabolism; Mice, Transgenic

Human CD34+ hematopoietic stem and progenitor cells (HSPCs) can reconstitute a human hemato-lymphoid system when transplanted into immunocompromised mice. Although fetal liver-derived and cord blood–derived CD34+ cells lead to high engraftment levels, engraftment of mobilized, adult donor-derived CD...