Metabolite Profiles of Flutamide in Serum from Patients with Flutamide-Induced Hepatic Dysfunction

• Published in: Biological & pharmaceutical bulletin Vol. 26; no. 10; pp. 1455 - 1460
• Main Authors: Takashima, Eiji, Iguchi, Kazuhiro, Usui, Shigeyuki, Yamamoto, Hajime, Hirano, Kazuyuki
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.10.2003; Maruzen; Japan Science and Technology Agency
• Subjects: Aged; Aged, 80 and over; Antineoplastic agents; Biological and medical sciences; Chemical and Drug Induced Liver Injury; flutamide; Flutamide - adverse effects; Flutamide - blood; Flutamide - chemistry; General aspects; hepatotoxicity; Humans; Liver Diseases - blood; Medical sciences; metabolite profile; Middle Aged; Pharmacology. Drug treatments; risk prediction; serum; Antineoplastic agent; Human; Biological fluid; Metabolite; Toxicity; Liver; metabolite profile; Antiandrogen; Antihormone; Flutamide; hepatotoxicity; risk prediction; Risk factor; Digestive diseases; Serum; Pharmacokinetics; Non steroid compound

Hepatic dysfunction due to flutamide administration has been reported and this side effect often limits the use of the agent. The prediction of flutamide-induced hepatotoxicity is attributed to the proper use of the antiandrogen. In this study, we investigated whether hepatic dysfunction could be as...