Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

• Published in: Cell reports (Cambridge) Vol. 30; no. 13; pp. 4418 - 4432.e4
• Main Authors: Chen, Michelle B., Yang, Andrew C., Yousef, Hanadie, Lee, Davis, Chen, Winnie, Schaum, Nicholas, Lehallier, Benoit, Quake, Stephen R., Wyss-Coray, Tony
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 31.03.2020
• Subjects: aging; Aging - blood; Aging - genetics; Aging - physiology; Animals; Arteries - physiology; Blood Circulation - physiology; blood-brain barrier; Brain - cytology; brain endothelial cells; Capillaries - physiology; Endothelial Cells - metabolism; Lipopolysaccharides - administration & dosage; Lipopolysaccharides - pharmacology; Male; Mice, Inbred C57BL; plasma proteome; rejuvenation; single-cell RNA sequencing; Transcription, Genetic - drug effects; Transcriptome - genetics; Veins - physiology; blood-brain barrier; single-cell RNA sequencing; brain endothelial cells; aging; rejuvenation; plasma proteome

Brain endothelial cells (BECs) are key constituents of the blood-brain barrier (BBB), protecting the brain from pathogens and restricting access of circulatory factors. Yet, because circulatory proteins have prominent age-related effects on adult neurogenesis, neuroinflammation, and cognitive functi...