β-Aminopropionitrile-induced aortic aneurysm and dissection in mice

The mechanistic basis for the formation of aortic aneurysms and dissection needs to be elucidated to facilitate the development of effective medications. β-Aminopropionitrile administration in mice has been used frequently to study the pathologic features and mechanisms of aortic aneurysm and dissec...

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Published inJVS-vascular science Vol. 3; pp. 64 - 72
Main Authors Sawada, Hisashi, Beckner, Zachary A., Ito, Sohei, Daugherty, Alan, Lu, Hong S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2022
Elsevier
Subjects
Aortic aneurysms
Aortic dissection
Mouse
β-Aminopropionitrile
Aortic aneurysms
Aortic dissection
Mouse
β-Aminopropionitrile
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Summary:The mechanistic basis for the formation of aortic aneurysms and dissection needs to be elucidated to facilitate the development of effective medications. β-Aminopropionitrile administration in mice has been used frequently to study the pathologic features and mechanisms of aortic aneurysm and dissection. This mouse model mimics several facets of the pathology of human aortic aneurysms and dissection, although many variables exist in the experimental design and protocols that must be resolved to determine its application to the human disease. In the present brief review, we have introduced the development of this mouse model and provided insights into understanding its pathologic features.
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ISSN:2666-3503
2666-3503
DOI:10.1016/j.jvssci.2021.12.002