Altered Synapse Stability in the Early Stages of Tauopathy

• Published in: Cell reports (Cambridge) Vol. 18; no. 13; pp. 3063 - 3068
• Main Authors: Jackson, Johanna S., Witton, Jonathan, Johnson, James D., Ahmed, Zeshan, Ward, Mark, Randall, Andrew D., Hutton, Michael L., Isaac, John T., O’Neill, Michael J., Ashby, Michael C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.03.2017; Cell Press; Elsevier
• Subjects: 2-photon microscopy; Animals; axon; Axons - metabolism; bouton; Cerebral Cortex - pathology; cortex; dementia; dendritic spine; Dendritic Spines - metabolism; Male; Mice, Transgenic; neurodegeneration; Presynaptic Terminals - metabolism; Synapses - pathology; Tauopathies - pathology; cortex; bouton; 2-photon microscopy; neurodegeneration; dementia; dendritic spine; axon

Synapse loss is a key feature of dementia, but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopa...