Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis

• Published in: Cell reports (Cambridge) Vol. 25; no. 1; pp. 118 - 129.e4
• Main Authors: Chhatbar, Chintan, Detje, Claudia N., Grabski, Elena, Borst, Katharina, Spanier, Julia, Ghita, Luca, Elliott, David A., Jordão, Marta Joana Costa, Mueller, Nora, Sutton, James, Prajeeth, Chittappen K., Gudi, Viktoria, Klein, Michael A., Prinz, Marco, Bradke, Frank, Stangel, Martin, Kalinke, Ulrich
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.10.2018; The Authors; Elsevier
• Subjects: Animals; astrocytes; Astrocytes - immunology; Astrocytes - pathology; Cell Communication - immunology; encephalitis; Encephalitis, Viral - genetics; Encephalitis, Viral - immunology; Encephalitis, Viral - pathology; Female; Humans; Male; Mice; Mice, Inbred C57BL; Microglia - immunology; Microglia - pathology; neurons; Neurons - immunology; Neurons - pathology; Receptor, Interferon alpha-beta - immunology; regulation of microglia activation; Signal Transduction; type I IFN receptor signaling; regulation of microglia activation; astrocytes; type I IFN receptor signaling; encephalitis; neurons

In sterile neuroinflammation, a pathological role is proposed for microglia, whereas in viral encephalitis, their function is not entirely clear. Many viruses exploit the odorant system and enter the CNS via the olfactory bulb (OB). Upon intranasal vesicular stomatitis virus instillation, we show an...