Activation of the Nrf2-ARE Pathway Ameliorates Hyperglycemia-Mediated Mitochondrial Dysfunction in Podocytes Partly Through Sirt1

• Published in: Cellular physiology and biochemistry Vol. 48; no. 1; pp. 1 - 15
• Main Authors: Zhang, Qunzi, Deng, Qiongxia, Zhang, Jun, Ke, JianTing, Zhu, Ye, Wen, Ruo wei, Ye, Zengchun, Peng, Hui, Su, Zhong zhen, Wang, Cheng, Lou, Tanqi
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2018; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: Adenosine Triphosphate - metabolism; Animals; Antioxidant response element; Antioxidants; Cell Line; Creatinine - urine; Deoxyribonucleic acid; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; DNA; Glucose - pharmacology; Humans; Hydroquinones - pharmacology; Hyperglycemia; Hyperglycemia - metabolism; Hyperglycemia - pathology; Inflammation; Injuries; Kidney diseases; Kinases; Male; Membrane Proteins - metabolism; Metabolism; Mice; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondrial DNA; NF-E2-Related Factor 2 - antagonists & inhibitors; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Original Paper; Oxidative stress; Permeability; Phosphorylation; Podocytes; Podocytes - cytology; Podocytes - drug effects; Podocytes - metabolism; Proteins; RNA Interference; RNA, Small Interfering - metabolism; Signal Transduction - drug effects; Sirt1; Sirtuin 1 - antagonists & inhibitors; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Superoxides - metabolism; Tert-butylhydroquinone; United States > US; Podocytes; Tert-butylhydroquinone; Sirt1; Antioxidant response element; Diabetes mellitus

Background/Aims: Previously we have shown that activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) attenuated hyperglycemia-induced damage in podocytes, but the molecular mechanism remains unknown. Methods: Tert-butylhydroquinone (t-BHQ) and small...