Sustained delivery of the bone morphogenetic proteins BMP-2 and BMP-7 for cartilage repair and regeneration in osteoarthritis

• Published in: Osteoarthritis and cartilage open Vol. 4; no. 1; p. 100240
• Main Authors: Whitty, Ciara, Pernstich, Christian, Marris, Charlotte, McCaskie, Andrew, Jones, Michael, Henson, Frances
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2022; Elsevier
• Subjects: BMP-2; BMP-7; Cartilage regeneration; Joint osteoarthritis; ORIGINAL PAPER; PODS; Sustained release; Joint osteoarthritis; BMP; Cartilage regeneration; BMP-7; Sustained release; PODS; BMP-2; BMP, Bone morphogenic protein; PODS, Polyhedrin delivery system

Attempts to utilise growth factors (GF) such as bone morphogenic proteins (BMPs) to treat osteoarthritis (OA) in the clinic have not secured widespread adoption. However, the novel crystalline GF formulation called PODS offers new perspectives. This study investigated the hypothesis that Polyhedrin...