Identification of protein kinase C domains involved in its translocation induced by propofol

• Published in: European journal of pharmacology Vol. 955; p. 175806
• Main Authors: Narasaki, Soshi, Noguchi, Soma, Urabe, Tomoaki, Harada, Kana, Hide, Izumi, Tanaka, Shigeru, Yanase, Yuhki, Kajimoto, Taketoshi, Uchida, Kazue, Tsutsumi, Yasuo M., Sakai, Norio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.09.2023
• Subjects: Endothelial nitric oxide synthase (eNOS); Propofol; Protein kinase C; Translocation; Translocation; Protein kinase C; Propofol; Endothelial nitric oxide synthase (eNOS)

Propofol is widely used for general anesthesia and sedation; however, the mechanisms of its anesthetic and adverse effects are not fully understood. We have previously shown that propofol activates protein kinase C (PKC) and induces its translocation in a subtype-specific manner. The purpose of this...