Regulatory T cell function in autoimmune disease

• Published in: Journal of translational autoimmunity (Online) Vol. 4; p. 100130
• Main Authors: Rajendiran, Anandhi, Tenbrock, Klaus
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2021; Elsevier
• Subjects: Foxp3; IL-2; Juvenile idiopathic arthritis; Regulatory T cells; SLE; VSI: Autoimmune disorder; IL-2; Foxp3; Regulatory T cells; SLE; Juvenile idiopathic arthritis

Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoi...