Regulatory T cell function in autoimmune disease

Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoi...

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Bibliographic Details
Published inJournal of translational autoimmunity (Online) Vol. 4; p. 100130
Main Authors Rajendiran, Anandhi, Tenbrock, Klaus
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2021
Elsevier
Subjects
Foxp3
IL-2
Juvenile idiopathic arthritis
Regulatory T cells
SLE
VSI: Autoimmune disorder
IL-2
Foxp3
Regulatory T cells
SLE
Juvenile idiopathic arthritis
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Summary:Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function. •Regulatory T cells are critical mediators of immune tolerance and critically depend on external IL-2.•Tregs are expanded during inflammation, where the local milieu enhances resistance to suppression in T effector cells.•Human Tregs are characterized by different markers, which hampers the comparability of studies in patients with autoimmunity.
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SourceType-Scholarly Journals-1
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ISSN:2589-9090
2589-9090
DOI:10.1016/j.jtauto.2021.100130