Regulatory T cell function in autoimmune disease

Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoi...

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Published inJournal of translational autoimmunity (Online) Vol. 4; p. 100130
Main Authors Rajendiran, Anandhi, Tenbrock, Klaus
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2021
Elsevier
Subjects
Foxp3
IL-2
Juvenile idiopathic arthritis
Regulatory T cells
SLE
VSI: Autoimmune disorder
IL-2
Foxp3
Regulatory T cells
SLE
Juvenile idiopathic arthritis
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Abstract Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function. •Regulatory T cells are critical mediators of immune tolerance and critically depend on external IL-2.•Tregs are expanded during inflammation, where the local milieu enhances resistance to suppression in T effector cells.•Human Tregs are characterized by different markers, which hampers the comparability of studies in patients with autoimmunity.
AbstractList Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function. • Regulatory T cells are critical mediators of immune tolerance and critically depend on external IL-2. • Tregs are expanded during inflammation, where the local milieu enhances resistance to suppression in T effector cells. • Human Tregs are characterized by different markers, which hampers the comparability of studies in patients with autoimmunity.
Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function.
Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function.Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function.
Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function. •Regulatory T cells are critical mediators of immune tolerance and critically depend on external IL-2.•Tregs are expanded during inflammation, where the local milieu enhances resistance to suppression in T effector cells.•Human Tregs are characterized by different markers, which hampers the comparability of studies in patients with autoimmunity.
ArticleNumber 100130
Author Rajendiran, Anandhi
Tenbrock, Klaus
Author_xml – sequence: 1
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  surname: Rajendiran
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  givenname: Klaus
  orcidid: 0000-0002-3566-227X
  surname: Tenbrock
  fullname: Tenbrock, Klaus
  email: ktenbrock@ukaachen.de
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35005594$$D View this record in MEDLINE/PubMed
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Keywords IL-2
Foxp3
Regulatory T cells
SLE
Juvenile idiopathic arthritis
Language English
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2021 The Authors. Published by Elsevier B.V.
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Snippet Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of...
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SubjectTerms Foxp3
IL-2
Juvenile idiopathic arthritis
Regulatory T cells
SLE
VSI: Autoimmune disorder
Title Regulatory T cell function in autoimmune disease
URI https://dx.doi.org/10.1016/j.jtauto.2021.100130
https://www.ncbi.nlm.nih.gov/pubmed/35005594
https://www.proquest.com/docview/2618515093
https://pubmed.ncbi.nlm.nih.gov/PMC8716637
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Volume 4
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