Mutagenesis and behavioral screening for altered circadian activity identifies the mouse mutant, Wheels

• Published in: Brain research Vol. 705; no. 1; pp. 255 - 266
• Main Authors: Pickard, Gary E., Sollars, Patricia J., Rinchik, Eugene M., Nolan, Patrick M., Bucan, Maja
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 24.12.1995; Amsterdam Elsevier; New York, NY
• Subjects: Animals; Behavior, Animal - physiology; Biological and medical sciences; Chromosome Mapping; Chronobiology; Circadian Rhythm - genetics; Fundamental and applied biological sciences. Psychology; Genotype; Light; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains - genetics; Motor Activity - genetics; Mutagenesis - physiology; Periodicity; Polymerase Chain Reaction; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Locomotion; Vertebrata; Regulation(control); Mammalia; Mouse; Rodentia; Biological rhythm; Behavior; Circadian rhythm

The molecular processes underlying the generation of circadian behavior in mammals are virtually unknown. To identify genes that regulate or alter circadian activity rhythms, a mouse mutagenesis program was initiated in conjunction with behavioral screening for alterations in circadian period (τ), a...