Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity

• Published in: International journal for parasitology -- drugs and drug resistance Vol. 8; no. 3; pp. 459 - 464
• Main Authors: Aguiar, Anna C.C., Murce, Erika, Cortopassi, Wilian A., Pimentel, Andre S., Almeida, Maria M.F.S., Barros, Daniele C.S., Guedes, Jéssica S., Meneghetti, Mario R., Krettli, Antoniana U.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.2018; Elsevier
• Subjects: Animals; Antimalarials - isolation & purification; Antimalarials - pharmacology; Antimalarials - therapeutic use; Chloroquine; Chloroquine - analogs & derivatives; Chloroquine - chemistry; Chloroquine - pharmacology; Chloroquine - therapeutic use; Drug Design; Drug Resistance; Hep G2 Cells; Humans; Malaria; Malaria - drug therapy; Mice; Parasitic Sensitivity Tests; Plasmodium berghei - drug effects; Plasmodium falciparum - drug effects; Regular article; Resistance; Resistance; Drug design; Malaria; Chloroquine

In spite of recent efforts to eradicate malaria in the world, this parasitic disease is still considered a major public health problem, with a total of 216 million cases of malaria and 445,000 deaths in 2016. Artemisinin-based combination therapies remain effective in most parts of the world, but re...